PRKAB1

PRKAB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CFE, 4CFF, 5EZV, 4ZHX,%%s4ZHX, 5EZV
Identifiers
Aliases	PRKAB1, AMPK, HAMPKb, protein kinase AMP-activated non-catalytic subunit beta 1
External IDs	MGI: 1336167 HomoloGene: 38160 GeneCards: PRKAB1
Gene location (Human) Chr. Chromosome 12 (human) Band n/a Start 119,667,753 bp End 119,681,630 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band n/a Start 116,013,586 bp End 116,024,508 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase activity • AMP-activated protein kinase activity • protein binding • protein kinase binding • kinase activity Cellular component • cytosol • protein complex • nucleotide-activated protein kinase complex • nucleus • nucleoplasm Biological process • protein heterooligomerization • lipid metabolic process • fatty acid metabolic process • protein phosphorylation • positive regulation of gene expression • fatty acid biosynthetic process • cell cycle arrest • regulation of protein kinase activity • regulation of catalytic activity • macroautophagy • signal transduction • regulation of signal transduction by p53 class mediator • nail development • regulation of macroautophagy • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5564	19079
Ensembl	ENSG00000111725	ENSMUSG00000029513
UniProt	Q9Y478	Q9R078
RefSeq (mRNA)	NM_006253	NM_031869
RefSeq (protein)	NP_006244 NP_006244.2	NP_114075
Location (UCSC)	Chr 12: 119.67 – 119.68 Mb	Chr 12: 116.01 – 116.02 Mb
PubMed search

AMPKBI
Identifiers
Symbol	AMPKBI
Pfam	PF04739
InterPro	IPR006828
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

4CFE, 4CFF, 5EZV, 4ZHX,%%s4ZHX, 5EZV

5564

19079

ENSG00000111725

ENSMUSG00000029513

Q9Y478

Q9R078

NM_006253

NM_031869

NP_006244
NP_006244.2

NP_114075

5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

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