PRIM1

PRIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BPU, 4BPW, 4BPX, 4LIK, 4LIL, 4MHQ, 4RR2, 5EXR
Identifiers
Aliases	PRIM1, p49, primase (DNA) subunit 1
External IDs	MGI: 97757 HomoloGene: 730 GeneCards: PRIM1
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • transferase activity • nucleotidyltransferase activity • metal ion binding • single-stranded DNA binding • DNA primase activity Cellular component • membrane • nucleoplasm • alpha DNA polymerase:primase complex • primosome complex Biological process • DNA replication • G1/S transition of mitotic cell cycle • telomere maintenance via recombination • DNA replication initiation • DNA replication, synthesis of RNA primer Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5557	19075
Ensembl	ENSG00000198056	ENSMUSG00000025395
UniProt	P49642	P20664
RefSeq (mRNA)	NM_000946	NM_008921
RefSeq (protein)	NP_000937	NP_032947.1 NP_032947
Location (UCSC)	Chr 12: 56.73 – 56.75 Mb	Chr 10: 128.02 – 128.03 Mb
PubMed search

4BPU, 4BPW, 4BPX, 4LIK, 4LIL, 4MHQ, 4RR2, 5EXR

5557

19075

ENSG00000198056

ENSMUSG00000025395

P49642

P20664

NM_000946

NM_008921

NP_000937

NP_032947.1
NP_032947

DNA primase small subunit is an enzyme that in humans is encoded by the PRIM1 gene.

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit.

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Wikipedia