PRELP

PRELP
Identifiers
Aliases	PRELP, MST161, MSTP161, SLRR2A, proline/arginine-rich end leucine-rich repeat protein, proline and arginine rich end leucine rich repeat protein
External IDs	MGI: 2151110 HomoloGene: 2041 GeneCards: PRELP
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 203,475,828 bp End 203,491,352 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 E4|1 58.02 cM Start 133,910,304 bp End 133,921,414 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparin binding • extracellular matrix structural constituent Cellular component • extracellular matrix • Golgi lumen • extracellular vesicle • lysosomal lumen • extracellular exosome • extracellular space • proteinaceous extracellular matrix • extracellular region Biological process • skeletal system development • cell aging • keratan sulfate biosynthetic process • keratan sulfate catabolic process • axonogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5549	116847
Ensembl	ENSG00000188783	ENSMUSG00000041577
UniProt	P51888	Q9JK53
RefSeq (mRNA)	NM_201348 NM_002725	NM_054077
RefSeq (protein)	NP_002716 NP_958505	NP_473418
Location (UCSC)	Chr 1: 203.48 – 203.49 Mb	Chr 1: 133.91 – 133.92 Mb
PubMed search

5549

116847

ENSG00000188783

ENSMUSG00000041577

P51888

Q9JK53

NM_201348
NM_002725

NM_054077

NP_002716
NP_958505

NP_473418

Prolargin is a protein that in humans is encoded by the PRELP gene.

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson–Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.

...
Wikipedia