PRDX6

PRDX6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PRX, 5B6N, 5B6M
Identifiers
Aliases	PRDX6, 1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29, peroxiredoxin 6
External IDs	MGI: 894320 HomoloGene: 3606 GeneCards: PRDX6
EC number	1.11.1.9
Gene ontology Molecular function • peroxidase activity • glutathione peroxidase activity • catalytic activity • protein binding • peroxiredoxin activity • oxidoreductase activity • hydrolase activity • ubiquitin protein ligase binding • antioxidant activity • cadherin binding Cellular component • cytoplasm • cytosol • membrane • lysosome • extracellular exosome • cytoplasmic vesicle • extracellular region • extracellular space • azurophil granule lumen Biological process • lipid metabolic process • response to reactive oxygen species • lipid catabolic process • hydrogen peroxide catabolic process • metabolic process • oxidation-reduction process • cellular oxidant detoxification • cell redox homeostasis • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9588	11758
Ensembl	ENSG00000117592	ENSMUSG00000026701
UniProt	P30041	O08709
RefSeq (mRNA)	NM_004905	NM_001303408 NM_007453
RefSeq (protein)	NP_004896	NP_031479.1 NP_001290337 NP_031479
Location (UCSC)	Chr 1: 173.48 – 173.49 Mb	Chr 1: 161.24 – 161.25 Mb
PubMed search

1PRX, 5B6N, 5B6M

9588

11758

ENSG00000117592

ENSMUSG00000026701

P30041

O08709

NM_004905

NM_001303408
NM_007453

NP_004896

NP_031479.1
NP_001290337
NP_031479

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene. It is a member of the peroxiredoxin family of antioxidant enzymes.

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

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Wikipedia