PRDX3

PRDX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JCG
Identifiers
Aliases	PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III, peroxiredoxin 3
External IDs	MGI: 88034 HomoloGene: 4944 GeneCards: PRDX3
Gene ontology Molecular function • peroxidase activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • kinase binding • protein C-terminus binding • protein binding • antioxidant activity • alkyl hydroperoxide reductase activity • peroxiredoxin activity • identical protein binding • oxidoreductase activity • protein kinase binding • thioredoxin peroxidase activity Cellular component • cytoplasm • cytosol • myelin sheath • mitochondrial matrix • early endosome • mitochondrion • IkappaB kinase complex • extracellular exosome Biological process • myeloid cell differentiation • peptidyl-cysteine oxidation • mitochondrion organization • negative regulation of apoptotic process • response to oxidative stress • regulation of mitochondrial membrane potential • cellular response to reactive oxygen species • response to lipopolysaccharide • maternal placenta development • positive regulation of NF-kappaB transcription factor activity • positive regulation of cell proliferation • hydrogen peroxide catabolic process • oxidation-reduction process • response to hydrogen peroxide • negative regulation of kinase activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular oxidant detoxification • cell redox homeostasis • apoptotic process • cellular response to oxidative stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10935	11757
Ensembl	ENSG00000165672	ENSMUSG00000024997
UniProt	P30048	P20108
RefSeq (mRNA)	NM_001302272 NM_006793 NM_014098	NM_007452
RefSeq (protein)	NP_001289201 NP_006784	NP_031478.1 NP_031478
Location (UCSC)	Chr 10: 119.17 – 119.18 Mb	Chr 19: 60.86 – 60.87 Mb
PubMed search

5JCG

10935

11757

ENSG00000165672

ENSMUSG00000024997

P30048

P20108

NM_001302272
NM_006793
NM_014098

NM_007452

NP_001289201
NP_006784

NP_031478.1
NP_031478

Thioredoxin-dependent peroxide reductase, mitochondrial is an enzyme that in humans is encoded by the PRDX3 gene. It is a member of the peroxiredoxin family of antioxidant enzymes.

This gene encodes a protein with antioxidant function and is localized in the . This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.

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