PRDX2

PRDX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QMV
Identifiers
Aliases	PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
External IDs	MGI: 109486 HomoloGene: 21182 GeneCards: PRDX2
Gene ontology Molecular function • oxidoreductase activity • antioxidant activity • peroxiredoxin activity • peroxidase activity • thioredoxin peroxidase activity Cellular component • cytoplasm • extracellular exosome • cytosol Biological process • removal of superoxide radicals • regulation of apoptotic process • cellular response to oxidative stress • negative regulation of apoptotic process • oxidation-reduction process • hydrogen peroxide catabolic process • response to reactive oxygen species • cell redox homeostasis • response to oxidative stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7001	21672
Ensembl	ENSG00000167815	ENSMUSG00000005161
UniProt	P32119	Q61171
RefSeq (mRNA)	NM_181738 NM_005809 NM_181737	NM_011563 NM_001317385
RefSeq (protein)	NP_005800	NP_035693.3 NP_001304314.1 NP_001304314 NP_035693
Location (UCSC)	Chr 19: 12.8 – 12.8 Mb	Chr 8: 84.97 – 84.97 Mb
PubMed search

1QMV

7001

21672

ENSG00000167815

ENSMUSG00000005161

P32119

Q61171

NM_181738
NM_005809
NM_181737

NM_011563
NM_001317385

NP_005800

NP_035693.3
NP_001304314.1
NP_001304314
NP_035693

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene.

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