PRDM9

PRDM9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IJD, 5EGB, 5EH2, 5EI9
Identifiers
Aliases	PRDM9, MEISETZ, MSBP3, PFM6, PRMD9, ZNF899, PR domain 9, PR/SET domain 9, KMT8B
External IDs	MGI: 2384854 HomoloGene: 104139 GeneCards: PRDM9
Gene ontology Molecular function • methyltransferase activity • transferase activity • metal ion binding • nucleic acid binding • histone-lysine N-methyltransferase activity Cellular component • nucleoplasm • intracellular • nucleus • chromosome Biological process • meiotic gene conversion • positive regulation of reciprocal meiotic recombination • histone lysine methylation • methylation • regulation of transcription, DNA-templated • meiotic cell cycle • transcription, DNA-templated • covalent chromatin modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56979	213389
Ensembl	ENSG00000164256	ENSMUSG00000051977
UniProt	Q9NQV7	Q96EQ9
RefSeq (mRNA)	NM_020227 NM_001310214	NM_144809
RefSeq (protein)	NP_001297143 NP_064612	NP_659058
Location (UCSC)	Chr 5: 23.44 – 23.53 Mb	Chr 17: 15.54 – 15.56 Mb
PubMed search

4IJD, 5EGB, 5EH2, 5EI9

56979

213389

ENSG00000164256

ENSMUSG00000051977

Q9NQV7

Q96EQ9

NM_020227
NM_001310214

NM_144809

NP_001297143
NP_064612

NP_659058

PR domain zinc finger protein 9 is a protein that in humans is encoded by the Prdm9 gene. The protein has histone H3K4 trimethyltransferase activity, a KRAB domain, and a DNA-binding domain consisting of multiple tandem C2H2 zinc finger (ZF) domains. PRDM9 specifically trimethylates lysine 4 of histone H3 during meiotic prophase and is essential for proper meiotic progression, but does not have the ability to mono- and dimethylate lysine 4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation which plays a central role in the transcriptional activation of genes during early meiotic prophase.

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