PRCP

PRCP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N2Z
Identifiers
Aliases	PRCP, HUMPCP, PCP, prolylcarboxypeptidase
External IDs	MGI: 1919711 HomoloGene: 55867 GeneCards: PRCP
Gene ontology Molecular function • serine-type carboxypeptidase activity • peptidase activity • protein binding • carboxypeptidase activity • serine-type peptidase activity • hydrolase activity • dipeptidyl-peptidase activity Cellular component • basal part of cell • plasma membrane • lysosome • extracellular exosome • azurophil granule membrane • ficolin-1-rich granule membrane Biological process • blood coagulation, intrinsic pathway • glucose homeostasis • regulation of reactive oxygen species metabolic process • energy homeostasis • plasma kallikrein-kinin cascade • regulation of thyroid hormone mediated signaling pathway • neutrophil degranulation • negative regulation of systemic arterial blood pressure • proteolysis • regulation of blood vessel endothelial cell migration • angiogenesis involved in wound healing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5547	72461
Ensembl	ENSG00000137509	ENSMUSG00000061119
UniProt	P42785	Q7TMR0
RefSeq (mRNA)	NM_005040 NM_199418 NM_001319214	NM_028243
RefSeq (protein)	NP_001306143 NP_005031 NP_955450	NP_082519.1 NP_082519
Location (UCSC)	Chr 11: 82.82 – 82.97 Mb	Chr 7: 92.87 – 92.93 Mb
PubMed search

3N2Z

5547

72461

ENSG00000137509

ENSMUSG00000061119

P42785

Q7TMR0

NM_005040
NM_199418
NM_001319214

NM_028243

NP_001306143
NP_005031
NP_955450

NP_082519.1
NP_082519

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Wikipedia