PPT1

PPT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GRO
Identifiers
Aliases	PPT1, CLN1, INCL, PPT, palmitoyl-protein thioesterase 1
External IDs	MGI: 1298204 HomoloGene: 7488 GeneCards: PPT1
Gene ontology Molecular function • palmitoyl-CoA hydrolase activity • palmitoyl hydrolase activity • hydrolase activity • palmitoyl-(protein) hydrolase activity • protein binding Cellular component • cytosol • Golgi apparatus • membrane • synaptic vesicle • synapse • axon • neuronal cell body • dendrite • lysosomal lumen • membrane raft • neuron projection • lysosome • extracellular exosome • nucleus • extracellular region • extracellular space Biological process • negative regulation of neuron apoptotic process • grooming behavior • positive regulation of pinocytosis • positive regulation of receptor-mediated endocytosis • lysosomal lumen acidification • associative learning • regulation of phospholipase A2 activity • response to stimulus • adult locomotory behavior • neuron development • negative regulation of apoptotic process • cellular protein catabolic process • receptor-mediated endocytosis • nervous system development • lipid catabolic process • cellular macromolecule catabolic process • brain development • membrane raft organization • protein catabolic process • sphingolipid catabolic process • negative regulation of cell growth • protein transport • protein depalmitoylation • cofactor metabolic process • pinocytosis • lysosome organization • cofactor transport • neurotransmitter secretion • regulation of synapse structure or activity • visual perception • fatty-acyl-CoA biosynthetic process • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5538	19063
Ensembl	ENSG00000131238	ENSMUSG00000028657
UniProt	P50897	O88531
RefSeq (mRNA)	NM_000310 NM_001142604	NM_008917
RefSeq (protein)	NP_000301 NP_001136076	NP_032943
Location (UCSC)	Chr 1: 40.07 – 40.1 Mb	Chr 4: 122.84 – 122.86 Mb
PubMed search

3GRO

5538

19063

ENSG00000131238

ENSMUSG00000028657

P50897

O88531

NM_000310
NM_001142604

NM_008917

NP_000301
NP_001136076

NP_032943

Palmitoyl-protein thioesterase 1 (PPT-1), also known as palmitoyl-protein hydrolase 1, is an enzyme that in humans is encoded by the PPT1 gene.

PPT-1 a member of the palmitoyl protein thioesterase family. PPT-1 is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. This enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues.

...
Wikipedia