PPRC1

PPRC1
Identifiers
Aliases	PPRC1, PRC, peroxisome proliferator-activated receptor gamma, coactivator-related 1
External IDs	MGI: 2385096 HomoloGene: 9006 GeneCards: PPRC1
Gene ontology Molecular function • ligand-dependent nuclear receptor transcription coactivator activity • nucleic acid binding • RNA polymerase II transcription cofactor activity • RNA binding • transcription cofactor activity • transcription factor binding Cellular component • nucleus • nucleoplasm Biological process • positive regulation of sequence-specific DNA binding transcription factor activity • mitochondrion organization • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23082	226169
Ensembl	ENSG00000148840	ENSMUSG00000055491
UniProt	Q5VV67	Q6NZN1
RefSeq (mRNA)	NM_001288727 NM_001288728 NM_015062	NM_001081214 NM_145504 NM_001346801
RefSeq (protein)	NP_001275656 NP_001275657 NP_055877	NP_001074683.1 NP_001074683 NP_001333730
Location (UCSC)	Chr 10: 102.13 – 102.15 Mb	Chr 19: 46.04 – 46.07 Mb
PubMed search

23082

226169

ENSG00000148840

ENSMUSG00000055491

Q5VV67

Q6NZN1

NM_001288727
NM_001288728
NM_015062

NM_001081214
NM_145504
NM_001346801

NP_001275656
NP_001275657
NP_055877

NP_001074683.1
NP_001074683
NP_001333730

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.

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