PPP3CA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V

Identifiers

Aliases

PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha

External IDs

MGI: 107164 HomoloGene: 55497 GeneCards: PPP3CA

Gene ontology
Molecular function	• calcium ion binding • phosphoprotein phosphatase activity • protein dimerization activity • calmodulin-dependent protein phosphatase activity • protein serine/threonine phosphatase activity • metal ion binding • calmodulin binding • protein binding • drug binding • protein heterodimerization activity • enzyme binding • calcium-dependent protein serine/threonine phosphatase activity • hydrolase activity • cyclosporin A binding
Cellular component	• postsynapse • membrane • plasma membrane • calcineurin complex • nucleoplasm • Z disc • mitochondrion • sarcolemma • nucleus • cytosol
Biological process	• multicellular organismal response to stress • negative regulation of insulin secretion • protein import into nucleus • transition between fast and slow fiber • negative regulation of chromatin binding • G1/S transition of mitotic cell cycle • response to amphetamine • protein dephosphorylation • calcineurin-NFAT signaling cascade • modulation of chemical synaptic transmission • positive regulation of sequence-specific DNA binding transcription factor activity • response to calcium ion • Fc-epsilon receptor signaling pathway • cellular response to drug • cardiac muscle hypertrophy in response to stress • negative regulation of dendrite morphogenesis • skeletal muscle fiber development • positive regulation of cardiac muscle hypertrophy in response to stress • excitatory postsynaptic potential • T cell activation • cellular response to glucose stimulus • calcium ion transport • calcium-mediated signaling • dephosphorylation • positive regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway, calcium modulating pathway • positive regulation of cardiac muscle hypertrophy • positive regulation of gene expression • negative regulation of gene expression • negative regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of connective tissue replacement • positive regulation of endocytosis • positive regulation of NFAT protein import into nucleus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5530


19055

Ensembl


ENSG00000138814


ENSMUSG00000028161

UniProt


Q08209


P63328

RefSeq (mRNA)


NM_001130692 NM_000944 NM_001130691


NM_001293622 NM_008913

RefSeq (protein)


NP_000935 NP_001124163 NP_001124164


NP_001280551 NP_032939

Location (UCSC)

Chr 4: 101.02 – 101.35 Mb

Chr 3: 136.67 – 136.94 Mb

PubMed search

1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V

NM_001130692
NM_000944
NM_001130691

NM_001293622
NM_008913

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