PPARGC1A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1XB7, 3B1M, 3CS8, 3D24, 3U9Q, 3V9T, 3V9V, 4QJR, 4QK4

Identifiers

Aliases

PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha

External IDs

MGI: 1342774 HomoloGene: 7485 GeneCards: PPARGC1A

Gene ontology
Molecular function	• promoter-specific chromatin binding • estrogen receptor binding • transcription factor binding • chromatin binding • protein binding • ligand-dependent nuclear receptor binding • nucleic acid binding • DNA binding • sequence-specific DNA binding • transcription coactivator activity • alpha-tubulin binding • RNA polymerase II transcription cofactor activity • androgen receptor binding • peroxisome proliferator activated receptor binding • ligand-dependent nuclear receptor transcription coactivator activity • RNA binding • chromatin DNA binding • ubiquitin protein ligase binding • transcription cofactor activity • receptor binding
Cellular component	• cytoplasm • cytosol • subsarcolemmal mitochondrion • cytosolic ribosome • nucleus • DNA-directed RNA polymerase II, core complex • apical dendrite • neuronal cell body • nuclear euchromatin • PML body • interfibrillar mitochondrion • nucleoplasm • intracellular membrane-bounded organelle
Biological process	• negative regulation of neuron apoptotic process • response to dietary excess • negative regulation of glycolytic process • response to fructose • cellular response to interleukin-6 • rhythmic process • cellular response to resveratrol • response to thyroid hormone • cellular response to fructose stimulus • cellular response to ionomycin • adaptive thermogenesis • response to ischemia • circadian rhythm • fatty acid oxidation • response to metformin • cellular response to caffeine • response to electrical stimulus involved in regulation of muscle adaptation • temperature homeostasis • cellular response to hypoxia • cellular response to glucose stimulus • positive regulation of fatty acid oxidation • cellular response to transforming growth factor beta stimulus • positive regulation of progesterone biosynthetic process • regulation of transcription, DNA-templated • cellular response to follicle-stimulating hormone stimulus • androgen metabolic process • response to reactive oxygen species • positive regulation of mitochondrial DNA metabolic process • digestion • response to leucine • response to norepinephrine • response to epinephrine • transcription, DNA-templated • negative regulation of mitochondrial fission • positive regulation of transcription, DNA-templated • positive regulation of glomerular visceral epithelial cell apoptotic process • response to nutrient levels • positive regulation of energy homeostasis • RNA splicing • skeletal muscle atrophy • cellular respiration • negative regulation of receptor activity • positive regulation of gluconeogenesis • transcription initiation from RNA polymerase II promoter • cellular response to potassium ion • negative regulation of neuron death • negative regulation of protein phosphorylation • positive regulation of cellular respiration • mRNA processing • protein stabilization • mitochondrion organization • positive regulation of sequence-specific DNA binding transcription factor activity • response to electrical stimulus • circadian regulation of gene expression • cerebellum development • positive regulation of ATP biosynthetic process • regulation of NMDA receptor activity • galactose metabolic process • positive regulation of muscle tissue development • regulation of circadian rhythm • flavone metabolic process • adipose tissue development • respiratory electron transport chain • positive regulation of cellular metabolic process • response to muscle activity • cellular response to nitrite • positive regulation of smooth muscle cell proliferation • gluconeogenesis • androgen receptor signaling pathway • negative regulation of smooth muscle cell proliferation • response to hypoxia • response to organic cyclic compound • protein complex assembly • cellular glucose homeostasis • cellular response to tumor necrosis factor • cellular response to estradiol stimulus • aging • negative regulation of smooth muscle cell migration • response to activity • positive regulation of histone acetylation • cellular response to fatty acid • mitophagy • cellular response to thyroid hormone stimulus • response to methionine • response to starvation • response to cold • cellular response to oxidative stress • forebrain development • cellular response to lipopolysaccharide • response to drug • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mitochondrion organization • brown fat cell differentiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10891


19017

Ensembl


ENSG00000109819


ENSMUSG00000029167

UniProt


Q9UBK2


O70343

RefSeq (mRNA)


NM_013261 NM_001330751 NM_001330752 NM_001330753


NM_008904

RefSeq (protein)


NP_001317680 NP_001317681 NP_001317682 NP_037393


NP_032930.1 NP_032930

Location (UCSC)

Chr 4: 23.76 – 23.9 Mb

Chr 5: 51.45 – 51.57 Mb

PubMed search

1XB7, 3B1M, 3CS8, 3D24, 3U9Q, 3V9T, 3V9V, 4QJR, 4QK4

NM_013261
NM_001330751
NM_001330752
NM_001330753

NM_008904

NP_001317680
NP_001317681
NP_001317682
NP_037393

...
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