PPARγ

PPARG

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP, 2HWQ, 2HWR, 2I4J, 2I4P, 2I4Z, 2OM9, 2P4Y, 2POB, 2PRG, 2Q59, 2Q5P, 2Q5S, 2Q61, 2Q6R, 2Q6S, 2Q8S, 2QMV, 2VSR, 2VST, 2VV0, 2VV1, 2VV2, 2VV3, 2VV4, 2XKW, 2YFE, 2ZK0, 2ZK1, 2ZK2, 2ZK3, 2ZK4, 2ZK5, 2ZK6, 2ZNO, 2ZVT, 3ADS, 3ADT, 3ADU, 3ADV, 3ADW, 3ADX, 3AN3, 3AN4, 3B0Q, 3B0R, 3B1M, 3B3K, 3BC5, 3CDP, 3CDS, 3CS8, 3CWD, 3D6D, 3DZU, 3DZY, 3E00, 3ET0, 3ET3, 3FEJ, 3FUR, 3G9E, 3GBK, 3H0A, 3HO0, 3HOD, 3IA6, 3K8S, 3KMG, 3LMP, 3NOA, 3OSI, 3OSW, 3PBA, 3PO9, 3PRG, 3QT0, 3R5N, 3R8A, 3R8I, 3S9S, 3SZ1, 3T03, 3TY0, 3U9Q, 3V9T, 3V9V, 3V9Y, 3VJH, 3VJI, 3VN2, 3VSO, 3VSP, 3WJ4, 3WJ5, 3WMH, 3X1H, 3X1I, 4A4V, 4A4W, 4CI5, 4E4K, 4E4Q, 4EM9, 4EMA, 4F9M, 4FGY, 4HEE, 4JAZ, 4JL4, 4L96, 4L98, 4O8F, 4OJ4, 4PRG, 4PVU, 4PWL, 4R2U, 4R6S, 4XLD, 4R06, 4Y29, 4XTA, 4XUM, 4YT1, 4XUH, 5F9B, 5AZV

Identifiers

Aliases

PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma

External IDs

MGI: 97747 HomoloGene: 7899 GeneCards: PPARG

Gene ontology
Molecular function	• protein binding • drug binding • alpha-actinin binding • activating transcription factor binding • chromatin binding • prostaglandin receptor activity • core promoter sequence-specific DNA binding • enzyme binding • protein phosphatase binding • metal ion binding • arachidonic acid binding • ligand-dependent nuclear receptor transcription coactivator activity • steroid hormone receptor activity • sequence-specific DNA binding • identical protein binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • estrogen receptor binding • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • DNA binding • transcription factor binding • double-stranded DNA binding • protein C-terminus binding • zinc ion binding • peptide binding • protein self-association • retinoid X receptor binding • protein heterodimerization activity • DBD domain binding • LBD domain binding
Cellular component	• cytosol • RNA polymerase II transcription factor complex • perinuclear region of cytoplasm • cytoplasm • nucleus • intracellular membrane-bounded organelle • nucleoplasm • protein complex
Biological process	• negative regulation of cell proliferation • epithelial cell differentiation • negative regulation of smooth muscle cell proliferation • positive regulation of oligodendrocyte differentiation • transcription, DNA-templated • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to lipid • negative regulation of receptor biosynthetic process • placenta development • cellular response to vitamin E • negative regulation of interferon-gamma-mediated signaling pathway • negative regulation of sequestering of triglyceride • regulation of fat cell differentiation • cellular response to retinoic acid • glucose homeostasis • negative regulation of collagen biosynthetic process • cellular response to hyperoxia • response to estrogen • regulation of cholesterol transporter activity • regulation of circadian rhythm • negative regulation of telomerase activity • signal transduction • cellular response to insulin stimulus • monocyte differentiation • regulation of transcription from RNA polymerase II promoter • regulation of blood pressure • positive regulation of apoptotic process • low-density lipoprotein particle receptor biosynthetic process • positive regulation of fat cell differentiation • negative regulation of cholesterol storage • regulation of transcription, DNA-templated • negative regulation of cell growth • response to drug • negative regulation of transcription, DNA-templated • cellular response to prostaglandin stimulus • animal organ regeneration • positive regulation of sequence-specific DNA binding transcription factor activity • lipoprotein transport • response to metformin • heart development • response to cold • negative regulation of acute inflammatory response • fatty acid oxidation • lipid homeostasis • transcription initiation from RNA polymerase II promoter • response to vitamin A • innate immune response • response to retinoic acid • cell maturation • cell fate commitment • peroxisome proliferator activated receptor signaling pathway • rhythmic process • response to mechanical stimulus • long-chain fatty acid transport • lipid metabolic process • response to low-density lipoprotein particle stimulus • response to caffeine • positive regulation of fatty acid oxidation • response to immobilization stress • positive regulation of phagocytosis, engulfment • negative regulation of pancreatic stellate cell proliferation • response to starvation • response to organic cyclic compound • regulation of transcription involved in cell fate commitment • regulation of lipid metabolic process • steroid hormone mediated signaling pathway • response to organic substance • response to nutrient • cellular response to prostaglandin E stimulus • negative regulation of transcription from RNA polymerase II promoter • white fat cell differentiation • negative regulation of macrophage derived foam cell differentiation • positive regulation of transcription from RNA polymerase II promoter • G-protein coupled receptor signaling pathway • macrophage derived foam cell differentiation • positive regulation of DNA binding • positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5468


19016

Ensembl


ENSG00000132170


ENSMUSG00000000440

UniProt


P37231


P37238

RefSeq (mRNA)


NM_005037 NM_015869 NM_138711 NM_138712 NM_001330615


NM_001127330 NM_011146 NM_001308352 NM_001308354

RefSeq (protein)


NP_001317544 NP_005028 NP_056953 NP_619725 NP_619726


NP_001120802 NP_001295281 NP_001295283 NP_035276

Location (UCSC)

Chr 3: 12.29 – 12.43 Mb

Chr 6: 115.36 – 115.49 Mb

PubMed search

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