PNKP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2BRF, 2W3O

Identifiers

PNKP, EIEE10, MCSZ, PNK, AOA4, polynucleotide kinase 3'-phosphatase

External IDs

Gene ontology
Molecular function	• transferase activity • nucleotide binding • ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity • kinase activity • damaged DNA binding • nucleotide kinase activity • protein binding • catalytic activity • purine nucleotide binding • endonuclease activity • double-stranded DNA binding • hydrolase activity • ATP binding • polynucleotide 3'-phosphatase activity
Cellular component	• membrane • nucleoplasm • nucleolus • nucleus • mitochondrion
Biological process	• DNA-dependent DNA replication • nucleotide-excision repair, DNA damage removal • positive regulation of telomere capping • phosphorylation • DNA 3' dephosphorylation involved in DNA repair • positive regulation of telomere maintenance via telomerase • response to oxidative stress • cellular response to DNA damage stimulus • nucleotide phosphorylation • positive regulation of telomerase activity • response to radiation • metabolic process • dephosphorylation • DNA damage response, detection of DNA damage • polynucleotide 3' dephosphorylation • DNA repair • nucleic acid phosphodiester bond hydrolysis • negative regulation of protein ADP-ribosylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


11284


59047


ENSG00000039650


ENSMUSG00000002963


Q96T60


Q9JLV6

RefSeq (mRNA)


NM_007254


NM_001290764 NM_001290766 NM_001290767 NM_021549

RefSeq (protein)


NP_009185


n/a

Location (UCSC)

PubMed search

n/a

Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene.

PNKP has been shown to interact with DNA polymerase beta and XRCC1.