PLXNA2

PLXNA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q3J
Identifiers
Aliases	PLXNA2, OCT, PLXN2, plexin A2
External IDs	MGI: 107684 HomoloGene: 56427 GeneCards: PLXNA2
Gene ontology Molecular function • protein binding • semaphorin receptor activity Cellular component • integral component of membrane • plasma membrane • semaphorin receptor complex • membrane • integral component of plasma membrane Biological process • somitogenesis • cell surface receptor signaling pathway • regulation of axon extension involved in axon guidance • cerebellar granule cell precursor tangential migration • branchiomotor neuron axon guidance • limb bud formation • neural tube development • semaphorin-plexin signaling pathway • signal transduction • pharyngeal system development • centrosome localization • regulation of cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5362	18845
Ensembl	ENSG00000076356	ENSMUSG00000026640
UniProt	O75051	P70207
RefSeq (mRNA)	NM_025179	NM_008882
RefSeq (protein)	NP_079455	NP_032908.2 NP_032908
Location (UCSC)	Chr 1: 208.02 – 208.24 Mb	Chr 1: 194.62 – 194.82 Mb
PubMed search

3Q3J

5362

18845

ENSG00000076356

ENSMUSG00000026640

O75051

P70207

NM_025179

NM_008882

NP_079455

NP_032908.2
NP_032908

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.

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