PLSCR3

PLSCR3
Identifiers
Aliases	PLSCR3, phospholipid scramblase 3
External IDs	MGI: 1917560 HomoloGene: 23219 GeneCards: PLSCR3
Gene location (Human) Chr. Chromosome 17 (human) Band n/a Start 7,389,727 bp End 7,394,843 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 69,846,376 bp End 69,852,058 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • phospholipid scramblase activity • calcium ion binding • protein binding • calcium-dependent protein binding Cellular component • integral component of membrane • plasma • mitochondrial membrane • membrane • mitochondrion Biological process • cholesterol homeostasis • cellular response to lipopolysaccharide • phospholipid scrambling • glucose homeostasis • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57048	70310
Ensembl	ENSG00000187838 ENSG00000284009	ENSMUSG00000019461
UniProt	Q9NRY6	Q9JIZ9
RefSeq (mRNA)	NM_020360 NM_001201576	NM_001168497 NM_023564
RefSeq (protein)	NP_001188505 NP_065093	NP_001161969 NP_076053
Location (UCSC)	Chr 17: 7.39 – 7.39 Mb	Chr 17: 69.85 – 69.85 Mb
PubMed search

57048

70310

ENSG00000187838
ENSG00000284009

ENSMUSG00000019461

Q9NRY6

Q9JIZ9

NM_020360
NM_001201576

NM_001168497
NM_023564

NP_001188505
NP_065093

NP_001161969
NP_076053

Phospholipid scramblase 3 is an enzyme that in humans is encoded by the PLSCR3 gene (abbreviated to PLS3 in this section). Like the other phospholipid scramblase family members (PLS1, PLS2, PLS4), PLS3 is a type II plasma membrane protein that is rich in proline and integral in apoptosis, or programmed cell death. The regulation of apoptosis is critical for both cell development and tissue homeostasis

Although phospholipid scramblase is thought to exist in all eukaryotic cells, PLS3 is a protein that is novel to the mitochondria. This is very important because are central in the apoptotic cell pathway. This newly found member of the scramblase family is "responsible for phospholipid translocation between two lipid compartments," the inner mitochondrial membrane and the outer membrane. Further experimental evidence suggests that the mechanism and effectors of PLS3's enzymatic activity are rather nuanced.

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Wikipedia