PLD2

PLD2
Identifiers
Aliases	PLD2, phospholipase D2, PLD1C
External IDs	MGI: 892877 HomoloGene: 55672 GeneCards: PLD2
Gene ontology Molecular function • phospholipase D activity • N-acylphosphatidylethanolamine-specific phospholipase D activity • protein binding • catalytic activity • phosphatidylinositol binding • hydrolase activity Cellular component • Golgi apparatus • endoplasmic reticulum membrane • membrane • plasma membrane • presynapse Biological process • Fc-gamma receptor signaling pathway involved in phagocytosis • lipid metabolic process • cell motility • small GTPase mediated signal transduction • lipid catabolic process • synaptic vesicle recycling • cytoskeleton organization • phosphatidic acid biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5338	18806
Ensembl	ENSG00000129219	ENSMUSG00000020828
UniProt	O14939	P97813
RefSeq (mRNA)	NM_001243108 NM_002663	NM_008876 NM_001302475 NM_001302476
RefSeq (protein)	NP_001230037 NP_002654	NP_001289404 NP_001289405 NP_032902
Location (UCSC)	Chr 17: 4.81 – 4.82 Mb	Chr 11: 70.54 – 70.56 Mb
PubMed search

5338

18806

ENSG00000129219

ENSMUSG00000020828

O14939

P97813

NM_001243108
NM_002663

NM_008876
NM_001302475
NM_001302476

NP_001230037
NP_002654

NP_001289404
NP_001289405
NP_032902

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM]

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Wikipedia