PLD1

Identifiers

PLD1, phospholipase D1

External IDs

MGI: 109585 HomoloGene: 116234 GeneCards: PLD1

Gene ontology
Molecular function	• phospholipase D activity • N-acylphosphatidylethanolamine-specific phospholipase D activity • protein binding • catalytic activity • phosphatidylinositol binding • hydrolase activity
Cellular component	• cytoplasm • late endosome membrane • Golgi membrane • endocytic vesicle • lysosomal membrane • apical plasma membrane • endoplasmic reticulum • perinuclear region of cytoplasm • endosome • endoplasmic reticulum membrane • membrane • Golgi apparatus • plasma membrane • specific granule membrane • tertiary granule membrane
Biological process	• regulation of microvillus assembly • lipid metabolic process • cell motility • small GTPase mediated signal transduction • lipid catabolic process • chemotaxis • Ras protein signal transduction • neutrophil degranulation • phosphatidic acid biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5337


18805

Ensembl


ENSG00000075651


ENSMUSG00000027695

UniProt


Q13393


Q9Z280

RefSeq (mRNA)


NM_001130081 NM_002662


NM_001164056 NM_008875

RefSeq (protein)


NP_001123553 NP_002653


n/a

Location (UCSC)

Chr 3: 171.6 – 171.81 Mb

Chr 3: 27.94 – 28.13 Mb

PubMed search

NM_001130081
NM_002662

NM_001164056
NM_008875

NP_001123553
NP_002653

n/a

Phospholipase D1 is an enzyme that in humans is encoded by the PLD1 gene.

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) EC 3.1.4.4 catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995).[supplied by OMIM]

Phospholipase D1 has been shown to interact with:

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