PKP3

PKP3
Identifiers
Aliases	PKP3, plakophilin 3
External IDs	MGI: 1891830 HomoloGene: 5200 GeneCards: PKP3
Gene ontology Molecular function • alpha-catenin binding • cell adhesion molecule binding • cadherin binding involved in cell-cell adhesion • RNA binding • protein binding • enzyme binding • translation regulator activity Cellular component • desmosome • nucleus • cell-cell junction • cell-cell adherens junction • cornified envelope • nucleoplasm • plasma membrane • cell junction • messenger ribonucleoprotein complex Biological process • single organismal cell-cell adhesion • desmosome assembly • cell adhesion • keratinization • cornification • regulation of translation • positive regulation of gene expression • negative regulation of mRNA catabolic process • protein localization to plasma membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11187	56460
Ensembl	ENSG00000184363	ENSMUSG00000054065
UniProt	Q9Y446	Q9QY23
RefSeq (mRNA)	NM_007183 NM_001303029	NM_001162924 NM_019762
RefSeq (protein)	NP_001289958 NP_009114	NP_001156396 NP_062736
Location (UCSC)	Chr 11: 0.39 – 0.4 Mb	Chr 7: 141.08 – 141.09 Mb
PubMed search

11187

56460

ENSG00000184363

ENSMUSG00000054065

Q9Y446

Q9QY23

NM_007183
NM_001303029

NM_001162924
NM_019762

NP_001289958
NP_009114

NP_001156396
NP_062736

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.

PKP3 has been shown to interact with:

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Wikipedia