PITX2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L7F, 2L7M, 2LKX

Identifiers

Aliases

PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4

External IDs

MGI: 109340 HomoloGene: 55454 GeneCards: PITX2

Gene ontology
Molecular function	• transcriptional repressor activity, RNA polymerase II transcription factor binding • identical protein binding • protein homodimerization activity • transcription regulatory region sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding • RNA polymerase II transcription coactivator activity • chromatin DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • chromatin binding • ribonucleoprotein complex binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • phosphoprotein binding
Cellular component	• nucleus • cytoplasm • transcription factor complex • nucleoplasm
Biological process	• response to vitamin A • female gonad development • vascular smooth muscle cell differentiation • regulation of transcription from RNA polymerase II promoter • skeletal muscle tissue development • cell proliferation involved in outflow tract morphogenesis • prolactin secreting cell differentiation • in utero embryonic development • pituitary gland development • vasculogenesis • regulation of cell proliferation • myoblast fusion • hair cell differentiation • spleen development • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • embryonic camera-type eye development • ventricular septum morphogenesis • endodermal digestive tract morphogenesis • determination of left/right symmetry • cardiac muscle tissue development • positive regulation of transcription, DNA-templated • subthalamic nucleus development • ventricular cardiac muscle cell development • left/right axis specification • hypothalamus cell migration • animal organ morphogenesis • regulation of cell migration • heart development • embryonic digestive tract morphogenesis • branching involved in blood vessel morphogenesis • cardiac muscle cell differentiation • digestive system development • multicellular organism development • atrioventricular valve development • pulmonary vein morphogenesis • cardiac neural crest cell migration involved in outflow tract morphogenesis • embryonic hindlimb morphogenesis • lung development • superior vena cava morphogenesis • positive regulation of DNA binding • extraocular skeletal muscle development • pulmonary myocardium development • deltoid tuberosity development • atrial cardiac muscle tissue morphogenesis • male gonad development • anatomical structure morphogenesis • brain development • neuron differentiation • odontogenesis of dentin-containing tooth • Wnt signaling pathway • left lung morphogenesis • somatotropin secreting cell differentiation • positive regulation of myoblast proliferation • camera-type eye development • response to hormone • odontogenesis • iris morphogenesis • neuron migration • negative regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5308


18741

Ensembl


ENSG00000164093


ENSMUSG00000028023

UniProt


Q99697


P97474

RefSeq (mRNA)

NM_000325 NM_001204397 NM_001204398 NM_001204399 NM_153426
NM_153427


NM_001042502 NM_001042504 NM_001286942 NM_001287048 NM_011098

RefSeq (protein)

NP_000316 NP_001191326 NP_001191327 NP_001191328 NP_700475
NP_700476


NP_001035967 NP_001035969 NP_001273871 NP_001273977 NP_035228

Location (UCSC)

Chr 4: 110.62 – 110.64 Mb

Chr 3: 129.2 – 129.22 Mb

PubMed search

2L7F, 2L7M, 2LKX

NM_001042502
NM_001042504
NM_001286942
NM_001287048
NM_011098

NP_700476

NP_001035967
NP_001035969
NP_001273871
NP_001273977
NP_035228

...
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