PILRA

PILRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WUZ, 3WV0, 4NFB
Identifiers
Aliases	PILRA, FDF03, paired immunoglobin like type 2 receptor alpha
External IDs	MGI: 2450529 HomoloGene: 8387 GeneCards: PILRA
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,367,530 bp End 100,400,099 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 137,821,952 bp End 137,836,281 bp
Gene ontology Molecular function • MHC class I protein binding • protein binding Cellular component • integral component of membrane • extracellular region • extracellular exosome • membrane • plasma membrane Biological process • viral process • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29992	231805
Ensembl	ENSG00000085514	ENSMUSG00000046245
UniProt	Q9UKJ1	Q2YFS3
RefSeq (mRNA)	NM_178273 NM_013439 NM_178272	NM_153510
RefSeq (protein)	NP_038467 NP_840056 NP_840057	NP_705730
Location (UCSC)	Chr 7: 100.37 – 100.4 Mb	Chr 7: 137.82 – 137.84 Mb
PubMed search

3WUZ, 3WV0, 4NFB

29992

231805

ENSG00000085514

ENSMUSG00000046245

Q9UKJ1

Q2YFS3

NM_178273
NM_013439
NM_178272

NM_153510

NP_038467
NP_840056
NP_840057

NP_705730

Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene.

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

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Wikipedia