PIK3R1

PIK3R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 5AUL
Identifiers
Aliases	PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1
External IDs	MGI: 97583 HomoloGene: 7889 GeneCards: PIK3R1
Gene ontology Molecular function • ErbB-3 class receptor binding • phosphatidylinositol 3-kinase regulator activity • insulin-like growth factor receptor binding • transmembrane receptor protein tyrosine kinase adaptor activity • insulin receptor binding • neurotrophin TRKA receptor binding • phosphatidylinositol 3-kinase regulatory subunit binding • transcription factor binding • insulin binding • phosphatidylinositol 3-kinase binding • 1-phosphatidylinositol-3-kinase regulator activity • protein binding • protein heterodimerization activity • insulin receptor substrate binding • protein phosphatase binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex • phosphatidylinositol 3-kinase complex, class IA • membrane • cell-cell junction • cis-Golgi network • plasma membrane • nucleus • perinuclear endoplasmic reticulum membrane • protein complex Biological process • positive regulation of glucose import • insulin-like growth factor receptor signaling pathway • negative regulation of cell adhesion • positive regulation of endoplasmic reticulum unfolded protein response • epidermal growth factor receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • negative regulation of osteoclast differentiation • positive regulation of cell migration • cellular glucose homeostasis • cellular response to UV • T cell costimulation • protein stabilization • negative regulation of apoptotic process • positive regulation of glucose import in response to insulin stimulus • response to endoplasmic reticulum stress • regulation of stress fiber assembly • positive regulation of establishment of protein localization to plasma membrane • negative regulation of cell-matrix adhesion • platelet activation • positive regulation of transcription factor import into nucleus • Fc-epsilon receptor signaling pathway • protein phosphorylation • phosphatidylinositol phosphorylation • vascular endothelial growth factor receptor signaling pathway • growth hormone receptor signaling pathway • regulation of phosphatidylinositol 3-kinase activity • intrinsic apoptotic signaling pathway in response to DNA damage • transport • cellular response to insulin stimulus • positive regulation of tumor necrosis factor production • positive regulation of RNA splicing • phosphatidylinositol biosynthetic process • protein transport • B cell differentiation • viral process • T cell receptor signaling pathway • NFAT protein import into nucleus • extrinsic apoptotic signaling pathway via death domain receptors • phosphatidylinositol-mediated signaling • leukocyte migration • positive regulation of transcription from RNA polymerase II promoter • signal transduction • regulation of establishment of protein localization to plasma membrane • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • ERBB2 signaling pathway • insulin receptor signaling pathway • axon guidance • regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5295	18708
Ensembl	ENSG00000145675	ENSMUSG00000041417
UniProt	P27986	P26450
RefSeq (mRNA)	NM_001242466 NM_181504 NM_181523 NM_181524	NM_001024955 NM_001077495
RefSeq (protein)	NP_001229395 NP_852556 NP_852664 NP_852665	NP_001070963.1 NP_001020126 NP_001070963
Location (UCSC)	Chr 5: 68.22 – 68.3 Mb	Chr 13: 101.68 – 101.77 Mb
PubMed search

1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 5AUL

5295

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