PIK3CA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP

Identifiers

Aliases

PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

External IDs

OMIM: 171834 MGI: 1206581 HomoloGene: 21249 GeneCards: PIK3CA

EC number

2.7.11.1

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activator activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • protein serine/threonine kinase activity • protein binding • phosphatidylinositol 3-kinase activity • insulin receptor substrate binding • ATP binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity
Cellular component	• phosphatidylinositol 3-kinase complex • cytosol • phosphatidylinositol 3-kinase complex, class IA • plasma membrane • lamellipodium
Biological process	• negative regulation of neuron apoptotic process • cardiac muscle contraction • epidermal growth factor receptor signaling pathway • protein kinase B signaling • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of multicellular organism growth • T cell costimulation • hypomethylation of CpG island • positive regulation of peptidyl-serine phosphorylation • platelet activation • Fc-epsilon receptor signaling pathway • phosphatidylinositol phosphorylation • vascular endothelial growth factor receptor signaling pathway • vasculature development • angiogenesis • insulin receptor signaling pathway via phosphatidylinositol 3-kinase • glucose metabolic process • phagocytosis • energy homeostasis • phosphatidylinositol biosynthetic process • negative regulation of fibroblast apoptotic process • regulation of gene expression • liver development • adipose tissue development • regulation of cellular respiration • T cell receptor signaling pathway • activation of protein kinase activity • regulation of genetic imprinting • negative regulation of anoikis • cellular response to glucose stimulus • endothelial cell migration • phosphatidylinositol-mediated signaling • leukocyte migration • regulation of phosphatidylinositol 3-kinase signaling • protein phosphorylation • ERBB2 signaling pathway • phosphatidylinositol-3-phosphate biosynthetic process • axon guidance • negative regulation of macroautophagy • phosphorylation • positive regulation of TOR signaling • anoikis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5290


18706

Ensembl


ENSG00000121879


ENSMUSG00000027665

UniProt


P42336


P42337

RefSeq (mRNA)


NM_006218


NM_008839

RefSeq (protein)


NP_006209


NP_032865.2 NP_032865

Location (UCSC)

Chr 3: 179.15 – 179.24 Mb

Chr 3: 32.4 – 32.47 Mb

PubMed search

2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP

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