PIGR

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1XED, 2OCW, 3CHN, 3CM9, 5D4K

Identifiers

Aliases

PIGR, Pigr, polymeric immunoglobulin receptor

External IDs

MGI: 103080 HomoloGene: 1984 GeneCards: PIGR

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q32.1	Start	206,928,518 bp
Band	1q32.1	End	206,946,466 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1 E4\|1 56.89 cM	Start	130,826,684 bp
Band	1 E4\|1 56.89 cM	End	130,852,249 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• polymeric immunoglobulin receptor activity
Cellular component	• integral component of membrane • extracellular region • receptor complex • integral component of plasma membrane • extracellular exosome • membrane • extracellular space • plasma membrane • azurophil granule membrane
Biological process	• Fc receptor signaling pathway • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor • retina homeostasis • detection of chemical stimulus involved in sensory perception of bitter taste • epidermal growth factor receptor signaling pathway • receptor clustering • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5284


18703

Ensembl


ENSG00000162896


ENSMUSG00000026417

UniProt


P01833


O70570

RefSeq (mRNA)


NM_002644


NM_011082

RefSeq (protein)


NP_002635


NP_035212

Location (UCSC)

Chr 1: 206.93 – 206.95 Mb

Chr 1: 130.83 – 130.85 Mb

PubMed search

1XED, 2OCW, 3CHN, 3CM9, 5D4K

Polymeric immunoglobulin receptor (pIgR) is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M. pIgRs are mainly located on the epithelial lining of mucosal surfaces of gastrointestinal, respiratory, and genitourinary tracts. The main function of pIgRs is the trancytosis of soluble IgA to the apical side of of mucosal epithelial.

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