PIAS1

PIAS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V66
Identifiers
Aliases	PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3, protein inhibitor of activated STAT 1
External IDs	MGI: 1913125 HomoloGene: 22953 GeneCards: PIAS1
Gene ontology Molecular function • DNA binding • transcription corepressor activity • transcription coactivator activity • zinc ion binding • transcription factor binding • metal ion binding • SUMO ligase activity • ligase activity • protein binding • androgen receptor binding • enzyme binding • ubiquitin protein ligase binding • protein C-terminus binding • protein domain specific binding • SUMO transferase activity Cellular component • PML body • nuclear speck • nucleoplasm • nucleus Biological process • androgen receptor signaling pathway • JAK-STAT cascade • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • protein sumoylation • GO:0006350 transcription, DNA-templated • regulation of interferon-gamma-mediated signaling pathway • regulation of cell proliferation • fat cell differentiation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • G1/S transition of mitotic cell cycle • visual learning • negative regulation of apoptotic process • positive regulation of smooth muscle cell differentiation • spermatogenesis • positive regulation of protein sumoylation • protein-DNA complex assembly • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8554	56469
Ensembl	ENSG00000033800	ENSMUSG00000032405
UniProt	O75925	O88907
RefSeq (mRNA)	NM_016166 NM_001320687	NM_019663
RefSeq (protein)	NP_001307616 NP_057250	NP_062637
Location (UCSC)	Chr 15: 68.05 – 68.2 Mb	Chr 9: 62.88 – 62.99 Mb
PubMed search

1V66

8554

56469

ENSG00000033800

ENSMUSG00000032405

O75925

O88907

NM_016166
NM_001320687

NM_019663

NP_001307616
NP_057250

NP_062637

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

PIAS1 has been shown to interact with:

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Wikipedia