PFOA

Perfluorooctanoic acid

Names
IUPAC name pentadecafluorooctanoic acid
Other names perfluorooctanoic acid, PFOA, C8, perfluorooctanoate, perfluorocaprylic acid, FC-143, F-n-octanoic acid, PFO
Identifiers
CAS Number	335-67-1 Y
3D model (Jmol)	Interactive image
ChEBI	CHEBI:35549 Y
ChemSpider	9180 Y
ECHA InfoCard	100.005.817
EC Number	206-397-9
PubChem CID	9554
RTECS number	RH0781000
InChI InChI=1S/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25) Y Key: SNGREZUHAYWORS-UHFFFAOYSA-N Y InChI=1/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25) Key: SNGREZUHAYWORS-UHFFFAOYAQ
SMILES FC(F)(C(F)(F)C(=O)O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Properties
Chemical formula	C8HF15O2
Molar mass	414.07 g/mol
Appearance	colorless liquid
Density	1.8 g/cm3
Melting point	40 to 50 °C (104 to 122 °F; 313 to 323 K)
Boiling point	189 to 192 °C (372 to 378 °F; 462 to 465 K)
Solubility in water	soluble, 9.5 g/L (PFO)
Solubility in other solvents	polar organic solvents
Acidity (pKa)	~0
Hazards
Main hazards	Strong Acid, Causes Burns
Safety data sheet
R-phrases (outdated)	R22 R34 R52/53
S-phrases (outdated)	S26 S36/37/39 S45
NFPA 704	0 3 0
Related compounds
Related compounds	Perfluorooctanesulfonic acid (PFOS), Perfluorononanoic acid (PFNA), Perfluorooctanesulfonamide (PFOSA), Trifluoroacetic acid (TFA)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y  (what is YN ?)
Infobox references

Perfluorooctanoic acid (PFOA) (conjugate base perfluorooctanoate), also known as C8, is a synthetic perfluorinated carboxylic acid and fluorosurfactant. One industrial application is as a surfactant in the emulsion polymerization of fluoropolymers. It has been used in the manufacture of such prominent consumer goods as polytetrafluoroethylene (commercially known as Teflon). PFOA has been manufactured since the 1940s in industrial quantities. It is also formed by the degradation of precursors such as some fluorotelomers.

PFOA persists indefinitely in the environment. It is a toxicant and carcinogen in animals. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range, and levels are higher in chemical plant employees and surrounding subpopulations. How general populations are exposed to PFOA is not completely understood. PFOA has been detected in industrial waste, stain resistant carpets, carpet cleaning liquids, house dust, microwave popcorn bags, water, food, some cookware and PTFE such as Teflon.

As a result of a class-action lawsuit and community settlement with DuPont, three epidemiologists conducted studies on the population surrounding a chemical plant that was exposed to PFOA at levels greater than in the general population. The studies concluded that there was probably an association between PFOA exposure and six health outcomes: kidney cancer, testicular cancer, ulcerative colitis, thyroid disease, hypercholesterolemia (high cholesterol), and pregnancy-induced hypertension.