PFKL

PFKL
Identifiers
Aliases	PFKL, ATP-PFK, PFK-B, PFK-L, phosphofructokinase, liver type
External IDs	MGI: 97547 HomoloGene: 55668 GeneCards: PFKL
Gene ontology Molecular function • transferase activity • nucleotide binding • monosaccharide binding • metal ion binding • kinase activity • fructose binding • kinase binding • protein binding • catalytic activity • identical protein binding • ATP binding • 6-phosphofructokinase activity • fructose-6-phosphate binding Cellular component • cytoplasm • membrane • 6-phosphofructokinase complex • extracellular exosome • cytosol • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen Biological process • negative regulation of insulin secretion • phosphorylation • canonical glycolysis • protein oligomerization • metabolic process • glycolytic process through fructose-6-phosphate • protein homotetramerization • glycolytic process • fructose 6-phosphate metabolic process • fructose 1,6-bisphosphate metabolic process • response to glucose • carbohydrate metabolic process • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5211	18641
Ensembl	ENSG00000141959	ENSMUSG00000020277
UniProt	P17858 Q7L2M7	P12382
RefSeq (mRNA)	NM_001002021 NM_002626	NM_008826
RefSeq (protein)	NP_001002021 NP_002617 NP_001002021.2 NP_002617.3	NP_032852
Location (UCSC)	Chr 21: 44.3 – 44.33 Mb	Chr 10: 77.99 – 78.01 Mb
PubMed search

5211

18641

ENSG00000141959

ENSMUSG00000020277

P17858
Q7L2M7

P12382

NM_001002021
NM_002626

NM_008826

NP_001002021
NP_002617
NP_001002021.2
NP_002617.3

NP_032852

6-phosphofructokinase, liver type (PFKL) is an enzyme that in humans is encoded by the PFKL gene on chromosome 21. This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

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