PDPK1

PDPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H1W, 1OKY, 1OKZ, 1UU3, 1UU7, 1UU8, 1UU9, 1UVR, 1W1D, 1W1G, 1W1H, 1Z5M, 2BIY, 2PE0, 2PE1, 2PE2, 2R7B, 2VKI, 2XCH, 2XCK, 3H9O, 3HRC, 3HRF, 3ION, 3IOP, 3NAX, 3NAY, 3NUN, 3NUS, 3NUU, 3NUY, 3ORX, 3ORZ, 3OTU, 3PWY, 3QC4, 3QCQ, 3QCS, 3QCX, 3QCY, 3QD0, 3QD3, 3QD4, 3RCJ, 3RWP, 3RWQ, 3SC1, 4A06, 4A07, 4AW0, 4AW1, 4CT1, 4CT2, 4RQV, 4RRV, 4XX9, 5ACK, 5HO7, 5HO8, 5HKM, 5HNG
Identifiers
Aliases	PDPK1, PDK1, PDPK2, PRO0461, PDPK2P, Phosphoinositide-dependent kinase-1, 3-phosphoinositide dependent protein kinase 1
External IDs	MGI: 1338068 HomoloGene: 37643 GeneCards: PDPK1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • phospholipase binding • insulin receptor binding • 3-phosphoinositide-dependent protein kinase activity • protein serine/threonine kinase activity • phospholipase activator activity • protein binding • ATP binding • protein kinase binding • kinase activity Cellular component • cytoplasm • cytosol • cell projection • membrane • focal adhesion • plasma membrane • nucleoplasm • cell junction • nucleus • perikaryon • postsynaptic density • cytoplasmic vesicle Biological process • activation of protein kinase B activity • intracellular signal transduction • regulation of transcription, DNA-templated • extrinsic apoptotic signaling pathway • negative regulation of protein kinase activity • phosphorylation • T cell costimulation • stimulatory C-type lectin receptor signaling pathway • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of transforming growth factor beta receptor signaling pathway • hyperosmotic response • transcription, DNA-templated • positive regulation of establishment of protein localization to plasma membrane • platelet activation • cellular response to epidermal growth factor stimulus • Fc-epsilon receptor signaling pathway • positive regulation of phospholipase activity • protein phosphorylation • negative regulation of cardiac muscle cell apoptotic process • focal adhesion assembly • negative regulation of toll-like receptor signaling pathway • peptidyl-serine phosphorylation • regulation of endothelial cell migration • cellular response to insulin stimulus • protein autophosphorylation • regulation of mast cell degranulation • peptidyl-threonine phosphorylation • type B pancreatic cell development • T cell receptor signaling pathway • cell migration • actin cytoskeleton organization • phosphatidylinositol-mediated signaling • regulation of I-kappaB kinase/NF-kappaB signaling • calcium-mediated signaling • negative regulation of neuron apoptotic process • cellular response to brain-derived neurotrophic factor stimulus • epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5170	18607
Ensembl	ENSG00000140992	ENSMUSG00000024122
UniProt	O15530	Q9Z2A0
RefSeq (mRNA)	NM_001261816 NM_002613 NM_031268	NM_001080773 NM_001286662 NM_011062
RefSeq (protein)	NP_001248745 NP_002604 NP_112558	NP_035192.2 NP_001074242 NP_001273591 NP_035192
Location (UCSC)	Chr 16: 2.54 – 2.6 Mb	Chr 17: 24.07 – 24.15 Mb
PubMed search

1H1W, 1OKY, 1OKZ, 1UU3, 1UU7, 1UU8, 1UU9, 1UVR, 1W1D, 1W1G, 1W1H, 1Z5M, 2BIY, 2PE0, 2PE1, 2PE2, 2R7B, 2VKI, 2XCH, 2XCK, 3H9O, 3HRC, 3HRF, 3ION, 3IOP, 3NAX, 3NAY, 3NUN, 3NUS, 3NUU, 3NUY, 3ORX, 3ORZ, 3OTU, 3PWY, 3QC4, 3QCQ, 3QCS, 3QCX, 3QCY, 3QD0, 3QD3, 3QD4, 3RCJ, 3RWP, 3RWQ, 3SC1, 4A06, 4A07, 4AW0, 4AW1, 4CT1, 4CT2, 4RQV, 4RRV, 4XX9, 5ACK, 5HO7, 5HO8, 5HKM, 5HNG

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