PDGFRβ

PDGFRB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG

Identifiers

Aliases

PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta

External IDs

MGI: 97531 HomoloGene: 1960 GeneCards: PDGFRB

Gene location (Human)

Chr.	Chromosome 5 (human)

Band	5q32	Start	150,113,837 bp
Band	5q32	End	150,155,872 bp

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)

Band	18 E1\|18 34.41 cM	Start	61,045,150 bp
Band	18 E1\|18 34.41 cM	End	61,085,061 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• vascular endothelial growth factor binding • kinase activity • platelet-derived growth factor-activated receptor activity • transmembrane receptor protein tyrosine kinase activity • receptor binding • ATP binding • protein kinase activity • platelet-derived growth factor binding • platelet activating factor receptor activity • transferase activity • platelet-derived growth factor receptor binding • protein binding • protein tyrosine kinase activity • protein kinase binding • platelet-derived growth factor beta-receptor activity • nucleotide binding • phosphatidylinositol 3-kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity • enzyme binding
Cellular component	• cytoplasm • membrane • focal adhesion • cell nucleus • apical plasma membrane • lysosome • extracellular exosome • integral component of membrane • plasma membrane • lysosomal lumen • intrinsic component of plasma membrane • cytoplasmic vesicle • cell surface
Biological process	• positive regulation of MAP kinase activity • positive regulation of phospholipase C activity • cell migration involved in vasculogenesis • cardiac myofibril assembly • positive regulation of smooth muscle cell migration • protein phosphorylation • response to lipid • positive regulation of phosphoprotein phosphatase activity • positive regulation of reactive oxygen species metabolic process • metanephric glomerular mesangial cell proliferation involved in metanephros development • positive regulation of ERK1 and ERK2 cascade • cell chemotaxis • inner ear development • metanephric S-shaped body morphogenesis • positive regulation of mitotic nuclear division • platelet-derived growth factor receptor-beta signaling pathway • positive regulation of collagen biosynthetic process • phosphatidylinositol metabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • cell migration involved in coronary angiogenesis • metanephric comma-shaped body morphogenesis • positive regulation of chemotaxis • positive regulation of DNA biosynthetic process • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • response to toxic substance • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • regulation of actin cytoskeleton organization • response to retinoic acid • phosphorylation • response to hyperoxia • retina vasculature development in camera-type eye • metanephric glomerulus morphogenesis • metanephric mesenchymal cell migration • wound healing • cellular response to platelet-derived growth factor stimulus • negative regulation of apoptotic process • response to fluid shear stress • response to estrogen • chemotaxis • metanephric mesenchyme development • response to hydrogen peroxide • positive regulation of smooth muscle cell proliferation • response to estradiol • intracellular signal transduction • response to organic cyclic compound • smooth muscle cell chemotaxis • positive regulation of cell migration • aorta morphogenesis • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • metanephric glomerular capillary formation • multicellular organism development • positive regulation of calcium ion import • glycosaminoglycan biosynthetic process • positive regulation of cell proliferation • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cell migration • signal transduction • positive regulation of Rho protein signal transduction • G-protein coupled receptor signaling pathway • phosphatidylinositol phosphorylation • positive regulation of hepatic stellate cell activation • positive regulation of fibroblast proliferation • positive regulation of apoptotic process • aging • male gonad development • lung growth • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of protein kinase B signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5159


18596

Ensembl


ENSG00000113721


ENSMUSG00000024620

UniProt


P09619


P05622

RefSeq (mRNA)


NM_002609 NM_001355016 NM_001355017


NM_001146268 NM_008809

RefSeq (protein)


NP_002600 NP_001341945 NP_001341946


NP_001139740 NP_032835

Location (UCSC)

Chr 5: 150.11 – 150.16 Mb

Chr 18: 61.05 – 61.09 Mb

PubMed search

1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG

NM_002609
NM_001355016
NM_001355017

NM_001146268
NM_008809

NP_002600
NP_001341945
NP_001341946

NP_001139740
NP_032835

...
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