PDGFD

PDGFD
Identifiers
Aliases	PDGFD, IEGF, SCDGF-B, SCDGFB, MSTP036, platelet derived growth factor D
External IDs	MGI: 1919035 HomoloGene: 11875 GeneCards: PDGFD
Gene ontology Molecular function • platelet-derived growth factor receptor binding • growth factor activity Cellular component • endoplasmic reticulum lumen • membrane • Golgi membrane • extracellular region • extracellular exosome • extracellular space Biological process • cellular response to transforming growth factor beta stimulus • positive regulation of smooth muscle cell chemotaxis • positive regulation of MAP kinase activity • positive regulation of fibroblast proliferation • positive regulation of cell migration • cellular response to platelet-derived growth factor stimulus • multicellular organism development • positive regulation of monocyte extravasation • positive regulation of protein autophosphorylation • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • cellular response to amino acid stimulus • positive regulation of phosphatidylinositol 3-kinase signaling • platelet-derived growth factor receptor signaling pathway • positive regulation of glomerular mesangial cell proliferation • positive regulation of cell division • positive regulation of smooth muscle cell proliferation • cellular response to hydrogen peroxide • regulation of peptidyl-tyrosine phosphorylation • blood coagulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80310	71785
Ensembl	ENSG00000170962	ENSMUSG00000032006
UniProt	Q9GZP0	Q925I7
RefSeq (mRNA)	NM_033135 NM_025208	NM_027924
RefSeq (protein)	NP_079484 NP_149126	NP_082200.1 NP_082200
Location (UCSC)	Chr 11: 103.91 – 104.16 Mb	Chr 9: 6.17 – 6.38 Mb
PubMed search

80310

71785

ENSG00000170962

ENSMUSG00000032006

Q9GZP0

Q925I7

NM_033135
NM_025208

NM_027924

NP_079484
NP_149126

NP_082200.1
NP_082200

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.

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