PDGFC

PDGFC
Identifiers
Aliases	PDGFC, FALLOTEIN, SCDGF, platelet derived growth factor C
External IDs	MGI: 1859631 HomoloGene: 9423 GeneCards: PDGFC
Gene ontology Molecular function • protein homodimerization activity • protein binding • growth factor activity • platelet-derived growth factor receptor binding Cellular component • Golgi membrane • nucleus • extracellular region • endoplasmic reticulum lumen • membrane • cell surface • extracellular exosome • plasma membrane • extracellular space • cytoplasm • cytosol Biological process • positive regulation of ERK1 and ERK2 cascade • cellular response to amino acid stimulus • positive regulation of cell proliferation • bone development • positive regulation of protein autophosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • multicellular organism development • activation of transmembrane receptor protein tyrosine kinase activity • central nervous system development • embryo development • positive regulation of cell division • positive regulation of cell migration • positive regulation of DNA replication • positive regulation of MAP kinase activity • animal organ morphogenesis • digestive tract development • regulation of peptidyl-tyrosine phosphorylation • positive regulation of fibroblast proliferation • platelet-derived growth factor receptor signaling pathway • blood coagulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56034	54635
Ensembl	ENSG00000145431	ENSMUSG00000028019
UniProt	Q9NRA1	Q8CI19
RefSeq (mRNA)	NM_016205	NM_019971
RefSeq (protein)	NP_057289	NP_064355.1 NP_064355
Location (UCSC)	Chr 4: 156.76 – 156.97 Mb	Chr 3: 81.04 – 81.21 Mb
PubMed search

56034

54635

ENSG00000145431

ENSMUSG00000028019

Q9NRA1

Q8CI19

NM_016205

NM_019971

NP_057289

NP_064355.1
NP_064355

Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.

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Wikipedia