PDE4D

PDE4D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU
Identifiers
Aliases	PDE4D, ACRDYS2, DPDE3, HSPDE43, PDE4DN2, STRK1, phosphodiesterase 4D
External IDs	HomoloGene: 129755 GeneCards: PDE4D
Genetically Related Diseases
breast cancer, obesity, smallpox, esophageal cancer, asthma
Targeted by Drug
rolipram
Gene ontology Molecular function • ATPase binding • scaffold protein binding • cAMP binding • metal ion binding • beta-2 adrenergic receptor binding • protein binding • drug binding • phosphoric diester hydrolase activity • enzyme binding • hydrolase activity • ubiquitin protein ligase binding • ion channel binding • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity Cellular component • cytoplasm • cytosol • centrosome • microtubule organizing center • apical plasma membrane • cytoskeleton • membrane • calcium channel complex • voltage-gated calcium channel complex • plasma membrane • nuclear membrane Biological process • establishment of endothelial barrier • smooth muscle contraction • positive regulation of interleukin-5 production • multicellular organism growth • aging • regulation of receptor activity • positive regulation of interferon-gamma production • neutrophil chemotaxis • positive regulation of interleukin-2 production • regulation of cAMP metabolic process • regulation of cell communication by electrical coupling involved in cardiac conduction • adrenergic receptor signaling pathway • cellular response to lipopolysaccharide • T cell receptor signaling pathway • adrenergic receptor signaling pathway involved in positive regulation of heart rate • cAMP-mediated signaling • cellular response to cAMP • signal transduction • leukocyte migration • negative regulation of relaxation of cardiac muscle • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • negative regulation of heart contraction • regulation of heart rate • regulation of ryanodine-sensitive calcium-release channel activity • cAMP catabolic process • cellular response to epinephrine stimulus • regulation of cardiac muscle cell contraction • negative regulation of peptidyl-serine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5144	n/a
Ensembl	ENSG00000113448	n/a
UniProt	Q08499	n/a
RefSeq (mRNA)	NM_001104631 NM_001165899 NM_001197218 NM_001197219 NM_001197220 NM_001197221 NM_001197222 NM_001197223 NM_006203 NM_001349241 NM_001349242 NM_001349243	n/a
RefSeq (protein)	NP_001098101 NP_001159371 NP_001184147 NP_001184148 NP_001184149 NP_001184150 NP_001184151 NP_001184152 NP_006194 NP_001336170 NP_001336171 NP_001336172	n/a
Location (UCSC)	Chr 5: 58.97 – 60.52 Mb	n/a
PubMed search		n/a

1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU

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