PDE4B

PDE4B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F
Identifiers
Aliases	PDE4B, DPDE4, PDEIVB, phosphodiesterase 4B
External IDs	MGI: 99557 HomoloGene: 1953 GeneCards: PDE4B
Genetically Related Diseases
Targeted by Drug
ibudilast, roflumilast, rolipram
Gene ontology Molecular function • metal ion binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • hydrolase activity • cAMP binding • gamma-tubulin binding • ion channel binding • phosphoric diester hydrolase activity • 3',5'-cyclic-AMP phosphodiesterase activity Cellular component • voltage-gated calcium channel complex • gamma-tubulin complex • cell periphery • cytosol • postsynaptic density • dendritic spine • membrane • centrosome • Z disc • excitatory synapse • synaptic vesicle Biological process • regulation of high voltage-gated calcium channel activity • neutrophil homeostasis • cellular response to drug • regulation of cardiac muscle cell contraction • positive regulation of interferon-gamma production • signal transduction • cellular response to lipopolysaccharide • positive regulation of interleukin-2 production • leukocyte migration • negative regulation of relaxation of cardiac muscle • cellular response to epinephrine stimulus • T cell receptor signaling pathway • neutrophil chemotaxis • cAMP catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5142	18578
Ensembl	ENSG00000184588	ENSMUSG00000028525
UniProt	Q07343	n/a
RefSeq (mRNA)	NM_001037339 NM_001037340 NM_001037341 NM_001297440 NM_001297441 NM_001297442 NM_002600	NM_001177980 NM_001177981 NM_001177982 NM_001177983 NM_019840
RefSeq (protein)	NP_001032416 NP_001032417 NP_001032418 NP_001284369 NP_001284370 NP_001284371 NP_002591 NP_001032418.1 NP_002591.2	n/a
Location (UCSC)	Chr 1: 65.79 – 66.37 Mb	Chr 4: 102.09 – 102.61 Mb
PubMed search

1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F

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