PDE2A

PDE2A

Protein PDE2A PDB 1mc0.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB

Identifiers

PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A

External IDs

MGI: 2446107 HomoloGene: 1952 GeneCards: PDE2A

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11q13.4	Start	72,576,141 bp
Band	11q13.4	End	72,674,591 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	n/a	Start	101,421,691 bp
Band	n/a	End	101,512,829 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • calcium channel activity • cGMP binding • metal ion binding • cyclic-nucleotide phosphodiesterase activity • protein binding • drug binding • phosphoric diester hydrolase activity • TPR domain binding • hydrolase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • cAMP binding • protein homodimerization activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity • identical protein binding
Cellular component	• cytoplasm • cytosol • Golgi apparatus • membrane • plasma membrane • mitochondrial matrix • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • presynaptic membrane • nucleus • mitochondrial outer membrane • mitochondrial inner membrane
Biological process	• establishment of endothelial barrier • cellular response to transforming growth factor beta stimulus • positive regulation of inflammatory response • cellular response to cGMP • protein targeting to mitochondrion • negative regulation of transcription from RNA polymerase II promoter • monocyte differentiation • cGMP-mediated signaling • cellular response to macrophage colony-stimulating factor stimulus • cellular response to mechanical stimulus • cellular response to drug • positive regulation of vascular permeability • cellular response to granulocyte macrophage colony-stimulating factor stimulus • negative regulation of cAMP biosynthetic process • metabolism • cAMP-mediated signaling • negative regulation of protein import into nucleus, translocation • signal transduction • negative regulation of vascular permeability • cGMP catabolic process • cAMP catabolic process • calcium ion transmembrane transport • G-protein coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


5138


207728


ENSG00000186642


ENSMUSG00000030653


O00408


Q922S4

RefSeq (mRNA)


NM_001143839 NM_001146209 NM_001243784 NM_002599


NM_001008548 NM_001143848 NM_001143849 NM_001243757 NM_001243758

RefSeq (protein)


NP_001137311 NP_001139681 NP_001230713 NP_002590


n/a

Location (UCSC)

Chr 11: 72.58 – 72.67 Mb

Chr 11: 101.42 – 101.51 Mb

PubMed search

1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB

ENSG00000186642

ENSMUSG00000030653

NM_001143839
NM_001146209
NM_001243784
NM_002599

NM_001008548
NM_001143848
NM_001143849
NM_001243757
NM_001243758

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Wikipedia

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