PCSK9

PCSK9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P4E, 2PMW, 2QTW, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 2XTJ, 3BPS, 3GCW, 3GCX, 3H42, 3M0C, 3P5B, 3P5C, 3SQO, 4K8R, 4NE9, 4NMX, 4OV6
Identifiers
Aliases	PCSK9, proprotein convertase subtilisin/kexin type 9, FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
External IDs	MGI: 2140260 HomoloGene: 17790 GeneCards: PCSK9
Gene ontology Molecular function • apolipoprotein binding • apolipoprotein receptor binding • very-low-density lipoprotein particle binding • low-density lipoprotein particle binding • protein self-association • sodium channel inhibitor activity • low-density lipoprotein particle receptor binding • very-low-density lipoprotein particle receptor binding • peptidase activity • protein binding • serine-type peptidase activity • receptor inhibitor activity • serine-type endopeptidase activity • hydrolase activity • RNA binding Cellular component • cytoplasm • endosome • late endosome • rough endoplasmic reticulum • Golgi apparatus • plasma membrane • PCSK9-AnxA2 complex • cell surface • early endosome • extrinsic component of external side of plasma membrane • endoplasmic reticulum • perinuclear region of cytoplasm • ER to Golgi transport vesicle • lysosome • PCSK9-LDLR complex • extracellular region • extracellular space • lysosomal membrane • endolysosome membrane Biological process • lipoprotein metabolic process • neurogenesis • steroid metabolic process • kidney development • positive regulation of receptor internalization • lipid metabolic process • negative regulation of low-density lipoprotein particle clearance • negative regulation of sodium ion transmembrane transporter activity • regulation of low-density lipoprotein particle receptor catabolic process • cellular response to starvation • regulation of neuron apoptotic process • protein processing • regulation of receptor activity • cholesterol metabolic process • protein autoprocessing • proteolysis • positive regulation of neuron apoptotic process • positive regulation of low-density lipoprotein particle receptor catabolic process • low-density lipoprotein receptor particle metabolic process • neuron differentiation • cellular response to insulin stimulus • lysosomal transport • low-density lipoprotein particle receptor catabolic process • phospholipid metabolic process • liver development • cholesterol homeostasis • triglyceride metabolic process • negative regulation of receptor recycling • apoptotic process • receptor-mediated endocytosis • negative regulation of low-density lipoprotein particle receptor binding • negative regulation of low-density lipoprotein receptor activity • negative regulation of receptor-mediated endocytosis involved in cholesterol transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	255738	100102
Ensembl	ENSG00000169174	ENSMUSG00000044254
UniProt	Q8NBP7	Q80W65
RefSeq (mRNA)	NM_174936	NM_153565
RefSeq (protein)	NP_777596	NP_705793.1 NP_705793
Location (UCSC)	Chr 1: 55.04 – 55.06 Mb	Chr 4: 106.44 – 106.46 Mb
PubMed search

2P4E, 2PMW, 2QTW, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 2XTJ, 3BPS, 3GCW, 3GCX, 3H42, 3M0C, 3P5B, 3P5C, 3SQO, 4K8R, 4NE9, 4NMX, 4OV6

255738

100102

ENSG00000169174

ENSMUSG00000044254

...
Wikipedia