PCK2

PCK2
Identifiers
Aliases	PCK2, PEPCK, PEPCK-M, PEphosphoenolpyruvate carboxykinase 2, mitochondrial
External IDs	MGI: 1860456 HomoloGene: 3356 GeneCards: PCK2
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2-q12 Start 24,094,053 bp End 24,110,598 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 C3|14 28.19 cM Start 55,540,266 bp End 55,550,017 bp
Gene ontology Molecular function • nucleotide binding • GTP binding • protein binding • carboxy-lyase activity • purine nucleotide binding • metal ion binding • lyase activity • phosphoenolpyruvate carboxykinase activity • phosphoenolpyruvate carboxykinase (GTP) activity Cellular component • mitochondrial matrix • extracellular exosome • mitochondrion Biological process • gluconeogenesis • positive regulation of insulin secretion • response to lipopolysaccharide • cellular response to tumor necrosis factor • oxaloacetate metabolic process • pyruvate metabolic process • NADH oxidation • response to dexamethasone • cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5106	74551
Ensembl	ENSG00000100889	ENSMUSG00000040618
UniProt	Q16822	Q8BH04
RefSeq (mRNA)	NM_001018073 NM_001291556 NM_001308054 NM_004563	NM_028994
RefSeq (protein)	NP_001018083 NP_001278485 NP_001294983 NP_004554	NP_083270
Location (UCSC)	Chr 14: 24.09 – 24.11 Mb	Chr 14: 55.54 – 55.55 Mb
PubMed search

5106

74551

ENSG00000100889

ENSMUSG00000040618

Q16822

Q8BH04

NM_001018073
NM_001291556
NM_001308054
NM_004563

NM_028994

NP_001018083
NP_001278485
NP_001294983
NP_004554

NP_083270

Phosphoenolpyruvate carboxykinase 2, mitochondrial (PCK2, PEPCK-M), is an isozyme of phosphoenolpyruvate carboxykinase (PCK, PEPCK) that in humans is encoded by the PCK2 gene on chromosome 14. This gene encodes a enzyme that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2014]

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Wikipedia