PCBP4

PCBP4
Identifiers
Aliases	PCBP4, CBP, LIP4, MCG10, poly(rC) binding protein 4
External IDs	MGI: 1890471 HomoloGene: 56926 GeneCards: PCBP4
Gene ontology Molecular function • DNA binding • nucleic acid binding • mRNA 3'-UTR binding • RNA binding Cellular component • cytoplasm • intracellular ribonucleoprotein complex • cytosol Biological process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of mRNA stability Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57060	59092
Ensembl	ENSG00000090097	ENSMUSG00000023495
UniProt	P57723	P57724
RefSeq (mRNA)	NM_001174100 NM_020418 NM_033008 NM_033009 NM_033010	NM_021567
RefSeq (protein)	NP_001167571 NP_065151 NP_127501 NP_127503	NP_067542.3 NP_067542
Location (UCSC)	Chr 3: 51.96 – 51.97 Mb	Chr 9: 106.45 – 106.46 Mb
PubMed search

57060

59092

ENSG00000090097

ENSMUSG00000023495

P57723

P57724

NM_001174100
NM_020418
NM_033008
NM_033009
NM_033010

NM_021567

NP_001167571
NP_065151
NP_127501
NP_127503

NP_067542.3
NP_067542

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.

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