PCBP3

PCBP3
Identifiers
Aliases	PCBP3, ALPHA-CP3, poly(rC) binding protein 3
External IDs	MGI: 1890470 HomoloGene: 23233 GeneCards: PCBP3
Gene ontology Molecular function • DNA binding • nucleic acid binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • double-stranded DNA binding • C-rich single-stranded DNA binding • RNA binding Cellular component • cytoplasm • cytosol • intracellular ribonucleoprotein complex • extracellular exosome • nucleus Biological process • mRNA metabolic process • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54039	59093
Ensembl	ENSG00000183570	ENSMUSG00000001120
UniProt	P57721	P57722
RefSeq (mRNA)	NM_020528 NM_001130141	NM_021568 NM_001347216
RefSeq (protein)	NP_001123613 NP_065389 NP_001335167 NP_001335168 NP_001335169 NP_001335170 NP_001335171 NP_001335172 NP_001335173 NP_001335174	NP_067543.2 NP_001334145 NP_067543
Location (UCSC)	Chr 21: 45.64 – 45.94 Mb	Chr 10: 76.76 – 76.96 Mb
PubMed search

54039

59093

ENSG00000183570

ENSMUSG00000001120

P57721

P57722

NM_020528
NM_001130141

NM_021568
NM_001347216

NP_001335170
NP_001335171
NP_001335172
NP_001335173
NP_001335174

NP_067543.2
NP_001334145
NP_067543

Poly(rC)-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene.

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene.

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