PCBP1

PCBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WVN, 1ZTG, 3VKE
Identifiers
Aliases	PCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
External IDs	MGI: 1345635 HomoloGene: 68506 GeneCards: PCBP1
Gene ontology Molecular function • DNA binding • protein binding • mRNA binding • RNA binding • nucleic acid binding • single-stranded DNA binding • sequence-specific single stranded DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • cadherin binding Cellular component • cytoplasm • intracellular ribonucleoprotein complex • extracellular exosome • membrane • nucleus • nucleoplasm • P-body • cytosol • nuclear speck Biological process • mRNA splicing, via spliceosome • gene expression • viral RNA genome replication • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5093	23983
Ensembl	ENSG00000169564	ENSMUSG00000051695
UniProt	Q15365	P60335
RefSeq (mRNA)	NM_006196	NM_011865
RefSeq (protein)	NP_006187	NP_035995.1 NP_035995
Location (UCSC)	Chr 2: 70.09 – 70.09 Mb	Chr 6: 86.52 – 86.53 Mb
PubMed search

1WVN, 1ZTG, 3VKE

5093

23983

ENSG00000169564

ENSMUSG00000051695

Q15365

P60335

NM_006196

NM_011865

NP_006187

NP_035995.1
NP_035995

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

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