PAX8

PAX8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K27
Identifiers
Aliases	PAX8, paired box 8
External IDs	MGI: 97492 HomoloGene: 2589 GeneCards: PAX8
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • thyroid-stimulating hormone receptor activity • protein binding • transcription regulatory region DNA binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • nucleoplasm • nucleus Biological process • regulation of apoptotic process • pronephros development • regulation of metanephric nephron tubule epithelial cell differentiation • cell differentiation • mesonephric tubule development • positive regulation of branching involved in ureteric bud morphogenesis • kidney epithelium development • regulation of transcription, DNA-templated • positive regulation of metanephric DCT cell differentiation • negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis • negative regulation of apoptotic process involved in metanephric collecting duct development • kidney development • pronephric field specification • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • anatomical structure morphogenesis • metanephric epithelium development • mesenchymal to epithelial transition involved in metanephros morphogenesis • transcription from RNA polymerase II promoter • regulation of thyroid-stimulating hormone secretion • transcription, DNA-templated • otic vesicle development • metanephric distal convoluted tubule development • negative regulation of mesenchymal cell apoptotic process involved in metanephros development • mesonephros development • positive regulation of transcription, DNA-templated • metanephric nephron tubule formation • multicellular organism development • central nervous system development • metanephric comma-shaped body morphogenesis • branching involved in ureteric bud morphogenesis • thyroid gland development • positive regulation of thyroid hormone generation • negative regulation of apoptotic process involved in metanephric nephron tubule development • S-shaped body morphogenesis • inner ear morphogenesis • urogenital system development • sulfur compound metabolic process • metanephric S-shaped body morphogenesis • metanephros development • cellular response to gonadotropin stimulus • positive regulation of transcription from RNA polymerase II promoter • thyroid-stimulating hormone signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7849	18510
Ensembl	ENSG00000125618	ENSMUSG00000026976
UniProt	Q06710	Q00288
RefSeq (mRNA)	NM_003466 NM_013951 NM_013952 NM_013953 NM_013992	NM_011040
RefSeq (protein)	NP_003457 NP_039246 NP_039247 NP_054698	NP_035170.1
Location (UCSC)	Chr 2: 113.22 – 113.28 Mb	Chr 2: 24.42 – 24.48 Mb
PubMed search

2K27

7849

18510

ENSG00000125618

ENSMUSG00000026976

Q06710

Q00288

NM_003466
NM_013951
NM_013952
NM_013953
NM_013992

NM_011040

NP_003457
NP_039246
NP_039247
NP_054698

NP_035170.1

Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene.

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. The PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining the normal function of some cells after birth. The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. PAX8 releases the hormones important for regulating growth, brain development, and metabolism. Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus. Additionally, PAX8 is expressed in the renal excretory system, epithelial cells of the endocervix, endometrium, ovary, Fallopian tube, seminal vesicle, epididymis, pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr).

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