PAX2

PAX2
Identifiers
Aliases	PAX2, PAPRS, FSGS7, paired box 2
External IDs	MGI: 97486 HomoloGene: 2968 GeneCards: PAX2
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.31 Start 100,735,603 bp End 100,829,941 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 C3|19 38.09 cM Start 44,756,045 bp End 44,837,871 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • superoxide-generating NADPH oxidase activity • transcription factor binding • core promoter proximal region sequence-specific DNA binding • protein binding • transcription regulatory region DNA binding Cellular component • Golgi apparatus • centriolar satellite • microtubule organizing center • protein complex • protein-DNA complex • nucleolus • lysosome • nucleus Biological process • cellular response to hydrogen peroxide • cellular response to glucose stimulus • cochlea development • pronephros development • cellular response to retinoic acid • regulation of metanephric nephron tubule epithelial cell differentiation • animal organ development • ureter development • cell differentiation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of branching involved in ureteric bud morphogenesis • regulation of transcription, DNA-templated • positive regulation of metanephric DCT cell differentiation • regulation of metanephros size • axonogenesis • protein kinase B signaling • negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis • negative regulation of apoptotic process involved in metanephric collecting duct development • positive regulation of epithelial cell proliferation • optic nerve morphogenesis • pronephric field specification • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • aging • metanephric epithelium development • mesenchymal to epithelial transition involved in metanephros morphogenesis • negative regulation of apoptotic process • glial cell differentiation • transcription from RNA polymerase II promoter • retinal pigment epithelium development • nephric duct formation • transcription, DNA-templated • stem cell differentiation • metanephric distal convoluted tubule development • reactive oxygen species metabolic process • negative regulation of mesenchymal cell apoptotic process involved in metanephros development • mesonephros development • optic nerve structural organization • positive regulation of transcription, DNA-templated • cellular response to epidermal growth factor stimulus • metanephric nephron tubule formation • positive regulation of metanephric glomerulus development • multicellular organism development • branching involved in ureteric bud morphogenesis • neural tube closure • response to nutrient levels • negative regulation of apoptotic process involved in metanephric nephron tubule development • ureter maturation • inner ear morphogenesis • cochlea morphogenesis • positive regulation of optic nerve formation • positive regulation of cell proliferation • optic cup morphogenesis involved in camera-type eye development • urogenital system development • cell fate determination • negative regulation of programmed cell death • vestibulocochlear nerve formation • camera-type eye development • metanephric collecting duct development • negative regulation of reactive oxygen species metabolic process • mesodermal cell fate specification • negative regulation of transcription, DNA-templated • metanephric mesenchyme development • optic chiasma development • optic nerve development • positive regulation of transcription from RNA polymerase II promoter • visual perception • negative regulation of cytolysis • brain morphogenesis • mesenchymal to epithelial transition • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5076	18504
Ensembl	ENSG00000075891	ENSMUSG00000004231
UniProt	Q02962 Q5SZP1	P32114
RefSeq (mRNA)	NM_003990 NM_000278 NM_001304569 NM_003987 NM_003988 NM_003989	NM_011037
RefSeq (protein)	NP_000269 NP_001291498 NP_003978 NP_003979 NP_003980 NP_003981	NP_035167
Location (UCSC)	Chr 10: 100.74 – 100.83 Mb	Chr 10: 44.76 – 44.84 Mb
PubMed search

5076

18504

ENSG00000075891

ENSMUSG00000004231

Q02962
Q5SZP1

P32114

NM_003989

NM_011037

NP_003981

NP_035167

Paired box gene 2, also known as PAX2 is a protein which in humans is encoded by the PAX2 gene.

The Pax Genes, or Paired-Box Containing Genes, play important roles in the development and proliferation of multiple cell lines, development of organs, and development and organization of the central nervous system. The transcription factor gene Pax2 is important in the regionalized embryological development of the central nervous system. In mammals, the brain is developed in three regions: the forebrain, midbrain, and the hindbrain. Concentration gradients of fibroblast growth factor 8 (FGF8) and Wingless-Type MMTV Integration Site Family, Member 1 (Wnt1) control expression of Pax2 during development of the Mesencephalon, or midbrain. Similar patterning during embryological development can be observed in “basal chordates or ascidians,” in which organization of the central nervous system in ascidian larvae are also controlled by fibroblast growth factor genes. The Pax2 gene encodes for the transcription factor which appears to be essential in the organization of the midbrain and hindbrain regions, and at the earliest can be detected on either side of the sulcus limitans, which separates motor and sensory nerve nuclei.

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Wikipedia