PARP4

PARP4
Identifiers
Aliases	PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193, poly(ADP-ribose) polymerase family member 4
External IDs	MGI: 2685589 HomoloGene: 124423 GeneCards: PARP4
Gene ontology Molecular function • transferase activity • DNA binding • transferase activity, transferring glycosyl groups • protein binding • enzyme binding • NAD+ ADP-ribosyltransferase activity Cellular component • cytoplasm • membrane • spindle • intracellular ribonucleoprotein complex • spindle microtubule • extracellular exosome • cytoskeleton • nucleus • cytosol Biological process • protein ADP-ribosylation • cell death • cellular response to DNA damage stimulus • cellular protein modification process • inflammatory response • DNA repair • response to drug • regulation of telomerase activity • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	143	328417
Ensembl	ENSG00000102699	ENSMUSG00000054509
UniProt	Q9UKK3	n/a
RefSeq (mRNA)	NM_006437	NM_001145978
RefSeq (protein)	NP_006428	n/a
Location (UCSC)	Chr 13: 24.42 – 24.51 Mb	Chr 14: 56.58 – 56.66 Mb
PubMed search

143

328417

ENSG00000102699

ENSMUSG00000054509

Q9UKK3

n/a

NM_006437

NM_001145978

NP_006428

n/a

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

PARP4 has been shown to interact with Major vault protein.

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