PAPSS2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2AX4

Identifiers

Aliases

PAPSS2, ATPSK2, BCYM4, SK2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2

External IDs

MGI: 1330223 HomoloGene: 55840 GeneCards: PAPSS2

Gene ontology
Molecular function	• ATP binding • nucleotidyltransferase activity • kinase activity • catalytic activity • nucleotide binding • transferase activity • sulfate adenylyltransferase (ATP) activity • adenylylsulfate kinase activity
Cellular component	• cytosol
Biological process	• blood coagulation • skeletal system development • bone development • phosphorylation • metabolic process • sulfate assimilation • 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9060


23972

Ensembl


ENSG00000198682


ENSMUSG00000024899

UniProt


O95340 Q5TB52


O88428

RefSeq (mRNA)


NM_004670 NM_001015880


NM_001201470 NM_011864

RefSeq (protein)


NP_001015880 NP_004661 NP_004661.2


NP_001188399 NP_035994

Location (UCSC)

Chr 10: 87.66 – 87.75 Mb

Chr 19: 32.62 – 32.67 Mb

PubMed search

NM_004670
NM_001015880

NM_001201470
NM_011864

NP_001015880
NP_004661
NP_004661.2

NP_001188399
NP_035994

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.

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