PABPC4
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| Aliases | PABPC4, APP-1, APP1, PABP4, iPABP, poly(A) binding protein cytoplasmic 4 | ||||||||||||||||
| External IDs | MGI: 2385206 HomoloGene: 37855 GeneCards: PABPC4 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 1: 39.56 – 39.58 Mb | Chr 4: 123.26 – 123.3 Mb | |||||||||||||||
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n/a
NM_003819
NM_001135653
NM_001135654
NP_001129125
NP_001129126
NP_003810
n/a
Polyadenylate-binding protein 4 (PABPC4) is a protein that in humans is encoded by the PABPC4 gene.
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.
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Wikipedia