P73

TP73
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GUQ, 1COK, 1DXS, 2KBY, 2MPS, 2WQI, 2WQJ, 2WTT, 2XWC, 3VD0, 3VD1, 3VD2, 4A63, 4G82, 4G83, 4GUO
Identifiers
Aliases	TP73, P73, tumor protein p73
External IDs	OMIM: 601990 MGI: 1336991 HomoloGene: 3960 GeneCards: TP73
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • p53 binding • transcription factor binding • chromatin binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • damaged DNA binding • protein binding • identical protein binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein kinase binding Cellular component • cytoplasm • cytosol • Golgi apparatus • intracellular membrane-bounded organelle • transcription factor complex • cell junction • chromatin • nucleus • mitochondrion • nucleoplasm Biological process • negative regulation of neuron apoptotic process • positive regulation of oligodendrocyte differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • kidney development • cellular response to UV • negative regulation of transcription from RNA polymerase II promoter • protein tetramerization • transcription, DNA-templated • cellular response to DNA damage stimulus • positive regulation of transcription, DNA-templated • activation of MAPK activity • mitotic G1 DNA damage checkpoint • cell cycle arrest • response to organonitrogen compound • intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitotic cell cycle • positive regulation of apoptotic process • regulation of gene expression • mismatch repair • cell cycle • negative regulation of cardiac muscle cell proliferation • viral process • negative regulation of JUN kinase activity • response to gamma radiation • response to X-ray • response to drug • positive regulation of transcription from RNA polymerase II promoter • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell proliferation • positive regulation of cell cycle arrest • apoptotic process • regulation of signal transduction by p53 class mediator • transcription from RNA polymerase II promoter • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7161	22062
Ensembl	ENSG00000078900	ENSMUSG00000029026
UniProt	O15350	Q9JJP2
RefSeq (mRNA)	NM_001126240 NM_001126241 NM_001126242 NM_001204184 NM_001204185 NM_001204186 NM_001204187 NM_001204188 NM_001204189 NM_001204190 NM_001204191 NM_001204192 NM_005427	NM_001126330 NM_001126331 NM_011642
RefSeq (protein)	NP_001119712 NP_001119713 NP_001119714 NP_001191113 NP_001191114 NP_001191115 NP_001191116 NP_001191117 NP_001191118 NP_001191119 NP_001191120 NP_001191121 NP_005418	NP_001119802.1 NP_001119803.1 NP_035772.2 NP_001119802 NP_001119803 NP_035772
Location (UCSC)	Chr 1: 3.65 – 3.74 Mb	Chr 4: 154.06 – 154.14 Mb
PubMed search

4GUQ, 1COK, 1DXS, 2KBY, 2MPS, 2WQI, 2WQJ, 2WTT, 2XWC, 3VD0, 3VD1, 3VD2, 4A63, 4G82, 4G83, 4GUO

7161

22062

ENSG00000078900

ENSMUSG00000029026

O15350

Q9JJP2

NM_001204186
NM_001204187
NM_001204188
NM_001204189
NM_001204190
NM_001204191
NM_001204192
NM_005427

...
Wikipedia