P70S6 kinase

RPS6KB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A60, 3A61, 3A62, 3WE4, 3WF5, 3WF6, 3WF7, 3WF8, 3WF9, 4L3J, 4L3L, 4L42, 4L43, 4L44, 4L45, 4L46, 4RLO, 4RLP
Identifiers
Aliases	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, P70-S6 Kinase 1, ribosomal protein S6 kinase B1, p70S6K, p70S6 kinase
External IDs	MGI: 1270849 HomoloGene: 81703 GeneCards: RPS6KB1
Gene location (Human) Chr. Chromosome 17 (human) Band n/a Start 59,893,046 bp End 59,950,564 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 86,498,871 bp End 86,544,805 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • PDZ domain binding • peptide binding • protein binding • identical protein binding • protein phosphatase 2A binding • protein serine/threonine/tyrosine kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • ribosomal protein S6 kinase activity Cellular component • cytoplasm • cytosol • membrane • synapse • nucleoplasm • cell surface • mitochondrial outer membrane • cell junction • mitochondrion • perinuclear region of cytoplasm • neuron projection • nucleus Biological process • germ cell development • response to amino acid • response to glucagon • response to organic cyclic compound • protein kinase B signaling • response to nutrient • phosphorylation • regulation of glucose import • response to testosterone • negative regulation of extrinsic apoptotic signaling pathway • G1/S transition of mitotic cell cycle • cellular response to growth factor stimulus • skeletal muscle contraction • response to mechanical stimulus • aging • response to leucine • cellular response to organic cyclic compound • positive regulation of mitotic cell cycle • negative regulation of apoptotic process • response to heat • response to glucocorticoid • response to glucose • response to peptide hormone • behavioral fear response • positive regulation of translation • response to organic substance • positive regulation of smooth muscle cell migration • response to tumor necrosis factor • response to insulin • response to lipopolysaccharide • negative regulation of insulin receptor signaling pathway • cellular response to hormone stimulus • long-term memory • response to wounding • TOR signaling • response to organonitrogen compound • response to electrical stimulus involved in regulation of muscle adaptation • skeletal muscle atrophy • cell cycle • response to ethanol • positive regulation of translational initiation • cell migration • response to toxic substance • positive regulation of skeletal muscle tissue growth • regulation of translation • response to drug • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of smooth muscle cell proliferation • apoptotic process • protein phosphorylation • cellular response to dexamethasone stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6198	72508
Ensembl	ENSG00000108443	ENSMUSG00000020516
UniProt	P23443	Q8BSK8
RefSeq (mRNA)	NM_001272042 NM_001272043 NM_001272044 NM_001272060 NM_003161	NM_001114334 NM_028259
RefSeq (protein)	NP_001258971 NP_001258972 NP_001258973 NP_001258989 NP_003152	NP_001107806 NP_082535
Location (UCSC)	Chr 17: 59.89 – 59.95 Mb	Chr 17: 86.5 – 86.54 Mb
PubMed search

3A60, 3A61, 3A62, 3WE4, 3WF5, 3WF6, 3WF7, 3WF8, 3WF9, 4L3J, 4L3L, 4L42, 4L43, 4L44, 4L45, 4L46, 4RLO, 4RLP

6198

72508

ENSG00000108443

ENSMUSG00000020516

P23443

Q8BSK8

...
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