P53 signaling pathway

TP53

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA

Identifiers

TP53, BCC7, LFS1, P53, TRP53, tumor protein p53

External IDs

OMIM: 191170 MGI: 98834 HomoloGene: 460 GeneCards: TP53

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17p13.1	Start	7,661,779 bp
Band	17p13.1	End	7,687,550 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11 B3\|11 42.83 cM	Start	69,580,359 bp
Band	11 B3\|11 42.83 cM	End	69,591,873 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein N-terminus binding • transcription factor activity, sequence-specific DNA binding • protein self-association • core promoter sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein phosphatase binding • ATP binding • transcription factor binding • metal ion binding • protein phosphatase 2A binding • enzyme binding • RNA polymerase II transcription factor binding • zinc ion binding • chromatin binding • protease binding • damaged DNA binding • protein binding • histone acetyltransferase binding • copper ion binding • protein kinase binding • chaperone binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • receptor tyrosine kinase binding • p53 binding • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding • RNA polymerase II regulatory region sequence-specific DNA binding • DNA binding
Cellular component	• cytoplasm • mitochondrion • nucleus • nuclear body • transcription factor TFIID complex • nuclear matrix • replication fork • nucleolus • endoplasmic reticulum • nuclear chromatin • nucleoplasm • protein complex • mitochondrial matrix • PML body • cytosol
Biological process	• positive regulation of histone deacetylation • chromatin assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • rhythmic process • replicative senescence • negative regulation of telomerase activity • oligodendrocyte apoptotic process • cellular response to DNA damage stimulus • cell aging • intrinsic apoptotic signaling pathway • positive regulation of neuron apoptotic process • cellular response to drug • regulation of mitochondrial membrane permeability • positive regulation of reactive oxygen species metabolic process • cellular response to ionizing radiation • positive regulation of thymocyte apoptotic process • negative regulation of helicase activity • cell cycle • Ras protein signal transduction • cell proliferation • cellular response to hypoxia • negative regulation of cell proliferation • nucleotide-excision repair • cellular response to glucose starvation • regulation of transcription, DNA-templated • response to antibiotic • transcription, DNA-templated • ER overload response • positive regulation of transcription, DNA-templated • negative regulation of cell growth • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of peptidyl-tyrosine phosphorylation • viral process • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • cell differentiation • determination of adult lifespan • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • cellular response to UV • DNA damage response, signal transduction by p53 class mediator • negative regulation of apoptotic process • protein tetramerization • oxidative stress-induced premature senescence • positive regulation of release of cytochrome c from mitochondria • circadian behavior • negative regulation of transcription, DNA-templated • protein localization • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of execution phase of apoptosis • protein complex assembly • DNA strand renaturation • multicellular organism development • cellular protein localization • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of gene expression • mitotic G1 DNA damage checkpoint • cell cycle arrest • positive regulation of protein oligomerization • positive regulation of apoptotic process • entrainment of circadian clock by photoperiod • response to X-ray • positive regulation of transcription from RNA polymerase II promoter • base-excision repair • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of cell cycle arrest • regulation of cell cycle G2/M phase transition • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of signal transduction by p53 class mediator • apoptotic process • transcription from RNA polymerase II promoter • positive regulation of protein export from nucleus • programmed cell death • regulation of apoptotic process • protein deubiquitination • phosphatidylinositol-mediated signaling • negative regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


7157


22059


ENSG00000141510


ENSMUSG00000059552


P04637


P02340

RefSeq (mRNA)

NM_001276761 NM_000546 NM_001126112 NM_001126113 NM_001126114
NM_001126115 NM_001126116 NM_001126117 NM_001126118 NM_001276695 NM_001276696 NM_001276697 NM_001276698 NM_001276699 NM_001276760


NM_001127233 NM_011640

RefSeq (protein)

NP_000537 NP_001119584 NP_001119585 NP_001119586 NP_001119587
NP_001119588 NP_001119589 NP_001119590 NP_001263624 NP_001263625 NP_001263626 NP_001263627 NP_001263628 NP_001263689 NP_001263690


NP_001120705 NP_035770

Location (UCSC)

Chr 17: 7.66 – 7.69 Mb

Chr 17: 69.58 – 69.59 Mb

PubMed search

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