P35-1

STX1A
Identifiers
Aliases	STX1A, HPC-1, P35-1, STX1, SYN1A, syntaxin 1A
External IDs	MGI: 109355 HomoloGene: 37941 GeneCards: STX1A
Gene ontology Molecular function • protein binding, bridging • calcium channel inhibitor activity • ion channel binding • protein domain specific binding • protein N-terminus binding • SNAP receptor activity • myosin binding • myosin head/neck binding • glycoprotein binding • ATP-dependent protein binding • calcium-dependent protein binding • kinase binding • protein binding • chloride channel inhibitor activity • protein heterodimerization activity • SNARE binding Cellular component • integral component of membrane • cytosol • membrane • synaptic vesicle • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex • voltage-gated potassium channel complex • plasma membrane • synapse • synaptic vesicle membrane • secretory granule • protein complex • extracellular region • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex • cell junction • SNARE complex • intracellular organelle • neuron projection • synaptobrevin 2-SNAP-25-syntaxin-1a complex • actomyosin • cytoplasmic vesicle • presynaptic membrane • postsynaptic density • presynaptic active zone membrane • nuclear membrane Biological process • exocytosis • positive regulation of norepinephrine secretion • synaptic vesicle docking • secretion by cell • regulation of insulin secretion • positive regulation of catecholamine secretion • positive regulation of neurotransmitter secretion • positive regulation of calcium ion-dependent exocytosis • regulation of exocytosis • glutamate secretion • response to gravity • vesicle docking • transport • positive regulation of excitatory postsynaptic potential • positive regulation of exocytosis • intracellular protein transport • neurotransmitter transport • neurotransmitter secretion • vesicle-mediated transport • calcium ion regulated exocytosis • regulation of synaptic vesicle priming • protein localization to membrane • modulation of excitatory postsynaptic potential • synaptic vesicle fusion to presynaptic active zone membrane • regulation of molecular function • SNARE complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6804	20907
Ensembl	ENSG00000106089	ENSMUSG00000007207
UniProt	Q16623 Q75ME0	O35526
RefSeq (mRNA)	NM_001165903 NM_004603	NM_016801
RefSeq (protein)	NP_001159375 NP_004594 NP_004594.1	NP_058081.2 NP_058081
Location (UCSC)	Chr 7: 73.7 – 73.72 Mb	Chr 5: 135.02 – 135.05 Mb
PubMed search

6804

20907

ENSG00000106089

ENSMUSG00000007207

Q16623
Q75ME0

O35526

NM_001165903
NM_004603

NM_016801

NP_001159375
NP_004594
NP_004594.1

NP_058081.2
NP_058081

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process.

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Wikipedia