P2RX7

P2RX7
Identifiers
Aliases	P2RX7, P2X7, purinergic receptor P2X 7
External IDs	MGI: 1339957 HomoloGene: 1925 GeneCards: P2RX7
Gene location (Human) Chr. Chromosome 12 (human) Band No data available Start 121,132,819 bp End 121,188,032 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band No data available Start 122,643,911 bp End 122,691,432 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • ATP binding • lipopolysaccharide binding • purinergic nucleotide receptor activity • protein homodimerization activity • channel activity • protein binding • receptor activity • ion channel activity • extracellular ATP-gated cation channel activity Cellular component • cytoplasm • membrane • cell-cell junction • synapse • integral component of membrane • neuromuscular junction • plasma membrane • neuronal cell body • bleb • integral component of nuclear inner membrane • integral component of plasma membrane • presynapse • external side of plasma membrane • postsynapse Biological process • cellular response to extracellular stimulus • positive regulation of protein phosphorylation • positive regulation of calcium ion transport into cytosol • regulation of sodium ion transport • multicellular organismal protein catabolic process • NAD transport • response to zinc ion • positive regulation of catalytic activity • response to organic substance • phospholipid transfer to membrane • T cell homeostasis • positive regulation of cytolysis • protein phosphorylation • cell surface receptor signaling pathway • membrane protein ectodomain proteolysis • phospholipid translocation • positive regulation of interleukin-1 beta production • apoptotic signaling pathway • positive regulation of gamma-aminobutyric acid secretion • calcium ion transport • defense response to Gram-positive bacterium • extrinsic apoptotic signaling pathway • synaptic vesicle exocytosis • ceramide biosynthetic process • positive regulation of cytokine secretion • response to mechanical stimulus • ion transport • reactive oxygen species metabolic process • phagolysosome assembly • regulation of killing of cells of other organism • positive regulation of prostaglandin secretion • positive regulation of interleukin-6 production • inflammatory response • plasma membrane organization • positive regulation of ion transmembrane transport • positive regulation of MAPK cascade • negative regulation of bone resorption • release of sequestered calcium ion into cytosol • cell volume homeostasis • cytolysis • phospholipid scrambling • positive regulation of lymphocyte apoptotic process • positive regulation of bone mineralization • skeletal system morphogenesis • cellular response to organic cyclic compound • membrane depolarization • mitochondrion organization • positive regulation of T cell mediated cytotoxicity • bleb assembly • collagen metabolic process • negative regulation of cell volume • pore complex assembly • response to electrical stimulus • cation transport • positive regulation of ossification • cation transmembrane transport • response to fluid shear stress • response to calcium ion • response to lipopolysaccharide • activation of MAPK activity • positive regulation of mitochondrial depolarization • positive regulation of interleukin-1 beta secretion • vesicle budding from membrane • negative regulation of MAPK cascade • positive regulation of protein secretion • homeostasis of number of cells within a tissue • sensory perception of pain • positive regulation of bleb assembly • response to ATP • gene expression • response to bacterium • response to organic cyclic compound • programmed cell death • positive regulation of interleukin-1 alpha secretion • protein processing • cellular response to dsRNA • T cell proliferation • positive regulation of gene expression • protein oligomerization • positive regulation of glutamate secretion • cell morphogenesis • positive regulation of cytoskeleton organization • positive regulation of apoptotic process • positive regulation of glycolytic process • response to drug • purinergic nucleotide receptor signaling pathway • blood coagulation • excitatory postsynaptic potential • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5027	18439
Ensembl	ENSG00000089041	ENSMUSG00000029468
UniProt	Q99572	Q9Z1M0
RefSeq (mRNA)	NM_002562 NM_177427	NM_001038839 NM_001038845 NM_001038887 NM_001284402 NM_011027
RefSeq (protein)	NP_002553	NP_001033928 NP_001033934 NP_001033976 NP_001271331 NP_035157
Location (UCSC)	Chr 12: 121.13 – 121.19 Mb	Chr 5: 122.64 – 122.69 Mb
PubMed search

5027

18439

ENSG00000089041

ENSMUSG00000029468

Q99572

Q9Z1M0

NM_002562
NM_177427

NM_001038839
NM_001038845
NM_001038887
NM_001284402
NM_011027

NP_002553

NP_001033928
NP_001033934
NP_001033976
NP_001271331
NP_035157

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.

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