P2RX3

P2RX3
Identifiers
Aliases	P2RX3, P2X3, purinergic receptor P2X 3
External IDs	MGI: 1097160 HomoloGene: 1922 GeneCards: P2RX3
Gene ontology Molecular function • purinergic nucleotide receptor activity • ion channel activity • ATP binding • extracellular ATP-gated cation channel activity Cellular component • integral component of membrane • rough endoplasmic reticulum • Golgi apparatus • membrane • receptor complex • dendritic spine • integral component of nuclear inner membrane • integral component of plasma membrane • neuronal cell body • terminal bouton • axon • membrane raft • neuron projection • plasma membrane Biological process • peristalsis • response to ATP • response to hypoxia • positive regulation of calcium-mediated signaling • positive regulation of calcium ion transport into cytosol • urinary bladder smooth muscle contraction • response to mechanical stimulus • cation transport • response to heat • ion transport • behavioral response to formalin induced pain • response to organic substance • cation transmembrane transport • regulation of synaptic plasticity • neuromuscular synaptic transmission • positive regulation of sensory perception of pain • behavioral response to pain • Q22291617 • response to cold • protein homooligomerization • response to carbohydrate • sensory perception of taste • signal transduction • neuronal action potential • response to temperature stimulus • chemical synaptic transmission • purinergic nucleotide receptor signaling pathway • blood coagulation • excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5024	228139
Ensembl	ENSG00000109991	ENSMUSG00000027071
UniProt	P56373	Q3UR32
RefSeq (mRNA)	NM_002559	NM_145526
RefSeq (protein)	NP_002550	NP_663501
Location (UCSC)	Chr 11: 57.34 – 57.37 Mb	Chr 2: 85 – 85.04 Mb
PubMed search

5024

228139

ENSG00000109991

ENSMUSG00000027071

P56373

Q3UR32

NM_002559

NM_145526

NP_002550

NP_663501

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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